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Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice

OBJECTIVE: In this study, we investigated the preventing effects of Curcumin (Cur) against titanium dioxide nanoparticle (NTiO(2))-induced mouse testicular damage. METHODS: We assessed NTiO(2)-intoxicated mice received 50mg/kg of NTiO(2) for 35 days. The Cur + NTiO(2) group was pretreated with Cur (...

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Autores principales: Karimi, Samaneh, Khorsandi, Layasadat, Nejaddehbashi, Fereshteh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brazilian Society of Assisted Reproduction 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798598/
https://www.ncbi.nlm.nih.gov/pubmed/31091065
http://dx.doi.org/10.5935/1518-0557.20190031
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author Karimi, Samaneh
Khorsandi, Layasadat
Nejaddehbashi, Fereshteh
author_facet Karimi, Samaneh
Khorsandi, Layasadat
Nejaddehbashi, Fereshteh
author_sort Karimi, Samaneh
collection PubMed
description OBJECTIVE: In this study, we investigated the preventing effects of Curcumin (Cur) against titanium dioxide nanoparticle (NTiO(2))-induced mouse testicular damage. METHODS: We assessed NTiO(2)-intoxicated mice received 50mg/kg of NTiO(2) for 35 days. The Cur + NTiO(2) group was pretreated with Cur (200 mg/kg) for 7 days prior to administering NTiO(2). Sperm parameters, testosterone concentration, histological criteria, morphometric parameters and Johnsen's scoring. RESULTS: NTiO(2) significantly reduced testicular weight, testosterone concentration, morphometric parameters, Johnsen's scoring and sperm quality (p<0.01), as well as a significant increase in histological criteria. Pretreatment with Cur reduced testicular weight, ameliorated morphometric parameters, increased Johnsen's scoring, elevated testosterone levels, and increased histological criteria such as vacuolization, detachment, and sloughing of germ cells into the seminiferous tubules. Cur also improved sperm parameters including sperm count, motility, and percentage of abnormality. CONCLUSION: Cur was found to have a potent protective effect against spermatogenesis defects induced by nanoparticles in mice.
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spelling pubmed-67985982019-10-22 Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice Karimi, Samaneh Khorsandi, Layasadat Nejaddehbashi, Fereshteh JBRA Assist Reprod Original Article OBJECTIVE: In this study, we investigated the preventing effects of Curcumin (Cur) against titanium dioxide nanoparticle (NTiO(2))-induced mouse testicular damage. METHODS: We assessed NTiO(2)-intoxicated mice received 50mg/kg of NTiO(2) for 35 days. The Cur + NTiO(2) group was pretreated with Cur (200 mg/kg) for 7 days prior to administering NTiO(2). Sperm parameters, testosterone concentration, histological criteria, morphometric parameters and Johnsen's scoring. RESULTS: NTiO(2) significantly reduced testicular weight, testosterone concentration, morphometric parameters, Johnsen's scoring and sperm quality (p<0.01), as well as a significant increase in histological criteria. Pretreatment with Cur reduced testicular weight, ameliorated morphometric parameters, increased Johnsen's scoring, elevated testosterone levels, and increased histological criteria such as vacuolization, detachment, and sloughing of germ cells into the seminiferous tubules. Cur also improved sperm parameters including sperm count, motility, and percentage of abnormality. CONCLUSION: Cur was found to have a potent protective effect against spermatogenesis defects induced by nanoparticles in mice. Brazilian Society of Assisted Reproduction 2019 /pmc/articles/PMC6798598/ /pubmed/31091065 http://dx.doi.org/10.5935/1518-0557.20190031 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivative License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited and the work is not changed in any way.
spellingShingle Original Article
Karimi, Samaneh
Khorsandi, Layasadat
Nejaddehbashi, Fereshteh
Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
title Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
title_full Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
title_fullStr Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
title_full_unstemmed Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
title_short Protective effects of Curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
title_sort protective effects of curcumin on testicular toxicity induced by titanium dioxide nanoparticles in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798598/
https://www.ncbi.nlm.nih.gov/pubmed/31091065
http://dx.doi.org/10.5935/1518-0557.20190031
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