Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report

Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Radical nephr...

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Autores principales: Sawazaki, Harutake, Tsujita, Yujiro, Ito, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798660/
https://www.ncbi.nlm.nih.gov/pubmed/31641593
http://dx.doi.org/10.1016/j.eucr.2019.101004
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author Sawazaki, Harutake
Tsujita, Yujiro
Ito, Yuji
author_facet Sawazaki, Harutake
Tsujita, Yujiro
Ito, Yuji
author_sort Sawazaki, Harutake
collection PubMed
description Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Radical nephrectomy was performed. Pathological diagnosis was MFH arising from the renal capsule. We used Ion AmpliSeq Cancer Hotspot Panel version 2 primers to perform gene mutation screening. We detected 13 mutations in 11 hotspot oncogenes (CSF1R, FGFR3, KDR, APC, PDGFRA, TP53, FLT3, ERBB4, KIT, STK11, RET), but these were not matched to driver mutations.
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spelling pubmed-67986602019-10-22 Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report Sawazaki, Harutake Tsujita, Yujiro Ito, Yuji Urol Case Rep Oncology Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Radical nephrectomy was performed. Pathological diagnosis was MFH arising from the renal capsule. We used Ion AmpliSeq Cancer Hotspot Panel version 2 primers to perform gene mutation screening. We detected 13 mutations in 11 hotspot oncogenes (CSF1R, FGFR3, KDR, APC, PDGFRA, TP53, FLT3, ERBB4, KIT, STK11, RET), but these were not matched to driver mutations. Elsevier 2019-09-05 /pmc/articles/PMC6798660/ /pubmed/31641593 http://dx.doi.org/10.1016/j.eucr.2019.101004 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Sawazaki, Harutake
Tsujita, Yujiro
Ito, Yuji
Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report
title Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report
title_full Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report
title_fullStr Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report
title_full_unstemmed Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report
title_short Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report
title_sort malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798660/
https://www.ncbi.nlm.nih.gov/pubmed/31641593
http://dx.doi.org/10.1016/j.eucr.2019.101004
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