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Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report
Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Radical nephr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798660/ https://www.ncbi.nlm.nih.gov/pubmed/31641593 http://dx.doi.org/10.1016/j.eucr.2019.101004 |
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author | Sawazaki, Harutake Tsujita, Yujiro Ito, Yuji |
author_facet | Sawazaki, Harutake Tsujita, Yujiro Ito, Yuji |
author_sort | Sawazaki, Harutake |
collection | PubMed |
description | Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Radical nephrectomy was performed. Pathological diagnosis was MFH arising from the renal capsule. We used Ion AmpliSeq Cancer Hotspot Panel version 2 primers to perform gene mutation screening. We detected 13 mutations in 11 hotspot oncogenes (CSF1R, FGFR3, KDR, APC, PDGFRA, TP53, FLT3, ERBB4, KIT, STK11, RET), but these were not matched to driver mutations. |
format | Online Article Text |
id | pubmed-6798660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-67986602019-10-22 Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report Sawazaki, Harutake Tsujita, Yujiro Ito, Yuji Urol Case Rep Oncology Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma. Renal MFH is rare and information about its molecular characterization is limited. We present here the case of a 77-year-old man who was incidentally found to have a huge right renal mass on computed tomography. Radical nephrectomy was performed. Pathological diagnosis was MFH arising from the renal capsule. We used Ion AmpliSeq Cancer Hotspot Panel version 2 primers to perform gene mutation screening. We detected 13 mutations in 11 hotspot oncogenes (CSF1R, FGFR3, KDR, APC, PDGFRA, TP53, FLT3, ERBB4, KIT, STK11, RET), but these were not matched to driver mutations. Elsevier 2019-09-05 /pmc/articles/PMC6798660/ /pubmed/31641593 http://dx.doi.org/10.1016/j.eucr.2019.101004 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Oncology Sawazaki, Harutake Tsujita, Yujiro Ito, Yuji Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report |
title | Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report |
title_full | Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report |
title_fullStr | Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report |
title_full_unstemmed | Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report |
title_short | Malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: A case report |
title_sort | malignant fibrous histiocytoma arising from the renal capsule and gene mutation screening: a case report |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798660/ https://www.ncbi.nlm.nih.gov/pubmed/31641593 http://dx.doi.org/10.1016/j.eucr.2019.101004 |
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