Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery

BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood. METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP. RESULTS: Individuals with CAD...

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Detalles Bibliográficos
Autores principales: Weaver, Kimberly N, Kochar, Bharati, Hansen, Jonathan J, Isaacs, Kim L, Jain, Animesh, Sheikh, Shehzad Z, Fichera, Alessandro, Chaumont, Nicole, Sadiq, Tim, Koruda, Mark, Long, Millie D, Herfarth, Hans H, Barnes, Edward L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Observations And Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798791/
https://www.ncbi.nlm.nih.gov/pubmed/31667470
http://dx.doi.org/10.1093/crocol/otz029
Descripción
Sumario:BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood. METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP. RESULTS: Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer disease duration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01–18.7). CONCLUSIONS: Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.

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