Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery

BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood. METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP. RESULTS: Individuals with CAD...

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Autores principales: Weaver, Kimberly N, Kochar, Bharati, Hansen, Jonathan J, Isaacs, Kim L, Jain, Animesh, Sheikh, Shehzad Z, Fichera, Alessandro, Chaumont, Nicole, Sadiq, Tim, Koruda, Mark, Long, Millie D, Herfarth, Hans H, Barnes, Edward L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Observations And Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798791/
https://www.ncbi.nlm.nih.gov/pubmed/31667470
http://dx.doi.org/10.1093/crocol/otz029
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author Weaver, Kimberly N
Kochar, Bharati
Hansen, Jonathan J
Isaacs, Kim L
Jain, Animesh
Sheikh, Shehzad Z
Fichera, Alessandro
Chaumont, Nicole
Sadiq, Tim
Koruda, Mark
Long, Millie D
Herfarth, Hans H
Barnes, Edward L
author_facet Weaver, Kimberly N
Kochar, Bharati
Hansen, Jonathan J
Isaacs, Kim L
Jain, Animesh
Sheikh, Shehzad Z
Fichera, Alessandro
Chaumont, Nicole
Sadiq, Tim
Koruda, Mark
Long, Millie D
Herfarth, Hans H
Barnes, Edward L
author_sort Weaver, Kimberly N
collection PubMed
description BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood. METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP. RESULTS: Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer disease duration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01–18.7). CONCLUSIONS: Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted.
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spelling pubmed-67987912019-10-28 Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery Weaver, Kimberly N Kochar, Bharati Hansen, Jonathan J Isaacs, Kim L Jain, Animesh Sheikh, Shehzad Z Fichera, Alessandro Chaumont, Nicole Sadiq, Tim Koruda, Mark Long, Millie D Herfarth, Hans H Barnes, Edward L Crohns Colitis 360 Observations And Research BACKGROUND: Risk factors for the development of chronic antibiotic dependent pouchitis (CADP) are not well understood. METHODS: Using multivariable logistic regression, we compared clinical factors between 194 patients with acute antibiotic responsive pouchitis or CADP. RESULTS: Individuals with CADP were significantly older (40.9 vs 30.8 years, P < 0.001) and demonstrated a longer disease duration before IPAA (10.3 vs 7.0 years, P = 0.004). Age ≥55 years at the time of IPAA was significantly associated with CADP (adjusted odds ratio = 4.35, 95% confidence interval = 1.01–18.7). CONCLUSIONS: Although older age should not represent a barrier to IPAA, further studies evaluating etiologies of this association are warranted. Oxford University Press 2019-10 2019-09-26 /pmc/articles/PMC6798791/ /pubmed/31667470 http://dx.doi.org/10.1093/crocol/otz029 Text en © 2019 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Observations And Research
Weaver, Kimberly N
Kochar, Bharati
Hansen, Jonathan J
Isaacs, Kim L
Jain, Animesh
Sheikh, Shehzad Z
Fichera, Alessandro
Chaumont, Nicole
Sadiq, Tim
Koruda, Mark
Long, Millie D
Herfarth, Hans H
Barnes, Edward L
Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
title Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
title_full Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
title_fullStr Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
title_full_unstemmed Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
title_short Chronic Antibiotic Dependent Pouchitis Is Associated With Older Age at the Time of Ileal Pouch Anal Anastomosis (J-pouch) Surgery
title_sort chronic antibiotic dependent pouchitis is associated with older age at the time of ileal pouch anal anastomosis (j-pouch) surgery
topic Observations And Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798791/
https://www.ncbi.nlm.nih.gov/pubmed/31667470
http://dx.doi.org/10.1093/crocol/otz029
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