2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease

OBJECTIVES/SPECIFIC AIMS: Identify objective neurological substrates of cognitive fatigue in Parkinson’s disease and in aging. METHODS/STUDY POPULATION: Structural and diffusion MRI. Behavioral assessments for aged adults and Parkinson’s disease. RESULTS/ANTICIPATED RESULTS: Gray and white matter de...

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Autores principales: Burke, Sarah Elizabeth, Samuel, Immanuel B. H., Zhou, Qing, Kluger, Benzi, Price, Catherine, Ding, Mingzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Mechanistic Basic to Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798902/
http://dx.doi.org/10.1017/cts.2017.210
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author Burke, Sarah Elizabeth
Samuel, Immanuel B. H.
Zhou, Qing
Kluger, Benzi
Price, Catherine
Ding, Mingzhou
author_facet Burke, Sarah Elizabeth
Samuel, Immanuel B. H.
Zhou, Qing
Kluger, Benzi
Price, Catherine
Ding, Mingzhou
author_sort Burke, Sarah Elizabeth
collection PubMed
description OBJECTIVES/SPECIFIC AIMS: Identify objective neurological substrates of cognitive fatigue in Parkinson’s disease and in aging. METHODS/STUDY POPULATION: Structural and diffusion MRI. Behavioral assessments for aged adults and Parkinson’s disease. RESULTS/ANTICIPATED RESULTS: Gray and white matter deficits that correlate with deficits in the basal ganglia for fatigued Parkinson’s disease patients Versus anterior cingulate cortex in healthy aged adults with fatigue. DISCUSSION/SIGNIFICANCE OF IMPACT: Over 50% of patients with Parkison’s disease and 38% of healthy older adults suffer from cognitive fatigue. However, diagnostics are limited to subjective surveys and there are no treatments for either population. Therefore, objective measures are greatly needed for better diagnosis and development of treatment targets.
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spelling pubmed-67989022019-10-28 2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease Burke, Sarah Elizabeth Samuel, Immanuel B. H. Zhou, Qing Kluger, Benzi Price, Catherine Ding, Mingzhou J Clin Transl Sci Mechanistic Basic to Clinical OBJECTIVES/SPECIFIC AIMS: Identify objective neurological substrates of cognitive fatigue in Parkinson’s disease and in aging. METHODS/STUDY POPULATION: Structural and diffusion MRI. Behavioral assessments for aged adults and Parkinson’s disease. RESULTS/ANTICIPATED RESULTS: Gray and white matter deficits that correlate with deficits in the basal ganglia for fatigued Parkinson’s disease patients Versus anterior cingulate cortex in healthy aged adults with fatigue. DISCUSSION/SIGNIFICANCE OF IMPACT: Over 50% of patients with Parkison’s disease and 38% of healthy older adults suffer from cognitive fatigue. However, diagnostics are limited to subjective surveys and there are no treatments for either population. Therefore, objective measures are greatly needed for better diagnosis and development of treatment targets. Cambridge University Press 2018-05-10 /pmc/articles/PMC6798902/ http://dx.doi.org/10.1017/cts.2017.210 Text en © The Association for Clinical and Translational Science 2018 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mechanistic Basic to Clinical
Burke, Sarah Elizabeth
Samuel, Immanuel B. H.
Zhou, Qing
Kluger, Benzi
Price, Catherine
Ding, Mingzhou
2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease
title 2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease
title_full 2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease
title_fullStr 2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease
title_full_unstemmed 2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease
title_short 2210: Anatomical substrates of cognitive fatigue in aging and in Parkinson’s disease
title_sort 2210: anatomical substrates of cognitive fatigue in aging and in parkinson’s disease
topic Mechanistic Basic to Clinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798902/
http://dx.doi.org/10.1017/cts.2017.210
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