Cargando…

2092: Chronic branched-chain amino acid ingestion aggravates hilar neuron loss in a rodent model of temporal lobe epilepsy

OBJECTIVES/SPECIFIC AIMS: We previously developed a translationally relevant model of temporal lobe epilepsy (TLE) in which glutamine synthetase is irreversibility inhibited by methionine sulfoximine (MSO), resulting in spontaneous seizures and dentate hilar neuron loss. The objective of this study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Evan Gruenbaum, Shaun, Dhaher, Roni, Rapuano, Amedeo, Eid, Tore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2018
Materias:	Mechanistic Basic to Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798929/ http://dx.doi.org/10.1017/cts.2017.200

Ejemplares similares

Astroglial Glutamine Synthetase and the Pathogenesis of Mesial Temporal Lobe Epilepsy
por: Sandhu, Mani Ratnesh S., et al.
Publicado: (2021)

2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain
por: Gruenbaum, Shaun E., et al.
Publicado: (2018)

3280 Mycobacterium bovis Bacille-Calmette-Guérin infection aggravates atherosclerosis
por: Huaman, Moises, et al.
Publicado: (2019)

4225 Evaluation of Neurotransmitters in Channelopathy-Related Epilepsy
por: Misra, Sunita N, et al.
Publicado: (2020)

Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy
por: Sandhu, Mani Ratnesh S., et al.
Publicado: (2020)

2172: Association between CYP450 polymorphisms and the use of complementary medicine among patients with drug-resistant epilepsy in Puerto Rico
por: Torres-Hernández, Bianca A., et al.
Publicado: (2018)

4346 Potential Sudden Unexpected Death in Epilepsy (SUDEP) Biomarkers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes with DEPDC5 Loss-of-Function
por: Zhao, Yanting, et al.
Publicado: (2020)

2529: Clinical determinants of clopidogrel responsiveness in a heterogeneous cohort of Caribbean Hispanics
por: Suarez, Dagmar Fredy Hernandez, et al.
Publicado: (2018)

2519: A quantitative disintegration method to evaluate polymeric films
por: Grab, Sheila, et al.
Publicado: (2018)

2370: Understanding epicardial fat biology by imaging
por: Stojanovska, Jadranka, et al.
Publicado: (2018)

3089 Clinicopathologic and Prognostic Significance of LGR5, a Cancer Stem cell Marker in Peritoneal Metastasis of a Colorectal Origin
por: Ihemelandu, Chukwuemeka
Publicado: (2019)

3332 Overexpression of CD44 is involved in the development of the early endometriotic lesion in a xenograft model
por: Knudtson, Jennifer, et al.
Publicado: (2019)

3127 The effect of common genetic variants in the oxytocin receptor gene on oxytocin response.
por: Malik, Manasi, et al.
Publicado: (2019)

2064: Deconstructing the peptide specificity of TCR recognition
por: Riley, Timothy P., et al.
Publicado: (2018)

3496 Mesenchymal Stem Cell Extracellular Vesicle Delivery in a Shear-Thinning Hydrogel For Therapy in an Acute Myocardial Infarction Model: A Comparative Analysis
por: Goldberg, Drew, et al.
Publicado: (2019)

3379 Associations between Diabetes Mellitus and Sublingual Microvascular Disease: A Prospective Cross-Sectional Study
por: Smilowitz, Nathaniel R, et al.
Publicado: (2019)

3559 Mechanisms of sebaceous skin microbial community remodeling through microenvironment modulation.
por: McCoy, William Howard, et al.
Publicado: (2019)

3268 A TL1 Team Approach to Personalizing Donor Human Milk for the Preterm Infant
por: Bendixen, Marion M, et al.
Publicado: (2019)

3285 Toxicity of Released B Cell Products in Multiple Sclerosis: Effects on Neurons and Oligodendrocytes
por: Zuroff, Leah, et al.
Publicado: (2019)

3424 Serial Biomarker Monitoring Predicts Long Term Outcomes in Acute Graft Versus Host Disease
por: Srinagesh, Hrishikesh Krishna, et al.
Publicado: (2019)

2399: Protective immunity to live vaccines among children with solid tumors
por: Garcia Robles, Franchesca, et al.
Publicado: (2018)

3024 Osteocyte-derived CXCL12 is Essential for Load-Induced Bone Formation in Adult Mice
por: Zuckerman, Pamela Cabahug, et al.
Publicado: (2019)

2097: Aging-associated increases in platelet granzyme A regulate pro-inflammatory gene synthesis by monocytes
por: Thomas Rondina, Matthew, et al.
Publicado: (2018)

3019 Metabolomic Markers of Methotrexate Response in Juvenile Idiopathic Arthritis
por: Funk, Ryan Sol, et al.
Publicado: (2019)

2188: Implanted multijoint functional electrical stimulation assistance improves walking efficiency after stroke: A case report
por: Makowski, Nathaniel, et al.
Publicado: (2018)

3296 Endometrial cancer microbiome biomarker for disease detection and microbial role in the disease
por: Walther-Antonio, Marina, et al.
Publicado: (2019)

2485: ETV6 represses Pax5 in early B-cell development
por: Kirkpatrick, Greg, et al.
Publicado: (2018)

3160 The Effects of Aging on the Rectal Mucosal CD4+ T cell Compartment and its Implications for HIV Transmission
por: Ackerley, Cassie Grimsley, et al.
Publicado: (2019)

2080: Therapeutic potential of mesenchymal stromal cells for hypoxic ischemic encephalopathy: A systematic review of preclinical studies
por: Moreira, Alvaro, et al.
Publicado: (2018)

2371: Perception- and behavior-related attention systems distinguished by phase amplitude coupling and high-gamma power
por: Varkki Chacko, Ravi, et al.
Publicado: (2018)

2367: Defining critical features of the immune microenvironment in melanoma using multiplex immunohistochemistry and spatial analysis
por: Gartrell, Robyn, et al.
Publicado: (2018)

3122 Longitudinal Recovery of Speech Motor Function Following Facial Transplantation
por: Perry, Bridget Jane, et al.
Publicado: (2019)

2392: Detecting cardiometabolic disease through breath analysis: A metabolomic approach
por: Choudary, Ahsan, et al.
Publicado: (2018)

3278 Gendered racism, psychological distress, and the strong Black woman
por: Baalbaki, Maha
Publicado: (2019)

3477 Impaired emotion recognition accuracy after right-hemisphere stroke
por: OConnell, Katherine, et al.
Publicado: (2019)

2180: hnRNP K overexpression drives acute myeloid leukemia emergence and progression
por: Hornbaker, Marisa, et al.
Publicado: (2018)

2114: The role of estrogen receptor-β in the development of the early endometriotic lesion
por: Knudtson, Jennifer, et al.
Publicado: (2018)

2477: Biofilms in wounds: Detection, individualizing treatment and monitoring response to therapy
por: Wilder-Smith, Petra, et al.
Publicado: (2018)

3173 A Mouse Model to Study Image-Guided, Radiation-Induced Cardiac Injury and Potential Clinically Targetable Biologic Mediators
por: Dreyfuss, Alexandra, et al.
Publicado: (2019)

3000 Olfactory habituation in schizophrenia
por: Estani, Patricia
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_70f3gd2cds82emkrevaqum2u0l