2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer

OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our path...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Muhan, Tiwary, Ekta, Arend, Rebecca, Miller, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Basic/Translational Science/Team Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799052/
http://dx.doi.org/10.1017/cts.2018.103
_version_ 1783460198622429184
author Hu, Muhan
Tiwary, Ekta
Arend, Rebecca
Miller, Michael
author_facet Hu, Muhan
Tiwary, Ekta
Arend, Rebecca
Miller, Michael
author_sort Hu, Muhan
collection PubMed
description OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer.
format Online
Article
Text
id pubmed-6799052
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-67990522019-10-28 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer Hu, Muhan Tiwary, Ekta Arend, Rebecca Miller, Michael J Clin Transl Sci Basic/Translational Science/Team Science OBJECTIVES/SPECIFIC AIMS: To understand the role of PGF2a and to characterize a novel cyclooxyrgenase (COX)-independent prostaglandin synthesis pathway in epithelial ovarian cancer. METHODS/STUDY POPULATION: We used high grade epithelial ovarian cancer cell line (OVCAR3) as a model to study our pathway. Our main mode of PGF2a detection is through mass spectrometry. RESULTS/ANTICIPATED RESULTS: Our current results suggest the OVCAR3 cells may synthesize PGF2a independently of COX enzymes. We anticipate this novel pathway may be dependent on the TGFb pathway. DISCUSSION/SIGNIFICANCE OF IMPACT: Understanding the role and synthesis pathway of PGF2a may allow us to uncover a novel therapeutic pathway for high grade ovarian cancer. Cambridge University Press 2018-11-21 /pmc/articles/PMC6799052/ http://dx.doi.org/10.1017/cts.2018.103 Text en © The Association for Clinical and Translational Science 2018 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic/Translational Science/Team Science
Hu, Muhan
Tiwary, Ekta
Arend, Rebecca
Miller, Michael
2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
title 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
title_full 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
title_fullStr 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
title_full_unstemmed 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
title_short 2336 Novel PGF2a synthesis pathway in epithelial ovarian cancer
title_sort 2336 novel pgf2a synthesis pathway in epithelial ovarian cancer
topic Basic/Translational Science/Team Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799052/
http://dx.doi.org/10.1017/cts.2018.103
work_keys_str_mv AT humuhan 2336novelpgf2asynthesispathwayinepithelialovariancancer
AT tiwaryekta 2336novelpgf2asynthesispathwayinepithelialovariancancer
AT arendrebecca 2336novelpgf2asynthesispathwayinepithelialovariancancer
AT millermichael 2336novelpgf2asynthesispathwayinepithelialovariancancer

Ejemplares similares