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3012 Functional consequences of pravastatin isomerization on OATP1B1-mediated transport

OBJECTIVES/SPECIFIC AIMS: In the present study, we examined the functional consequences of 3α-PVA on OATP1B1-mediated PVA transport. To elucidate this, we determined the effect of SLCO1B1 genotype on PVA transport and the role of 3αPVA as a competitive inhibitor of OATP1B1, which could serve as anot...

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Detalles Bibliográficos
Autores principales:	Wagner, Jonathan, Ruggiero, Melissa, Steven Leeder, J., Hagenbuch, Bruno
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2019
Materias:	Mechanistic Basic to Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799086/ http://dx.doi.org/10.1017/cts.2019.243

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