3236 Identification of exhaustive markers in cytotoxic T-cells to guide immune modulation in hepatocellular carcinoma ex vivo

OBJECTIVES/SPECIFIC AIMS: Objective: apply checkpoint inhibitors that are specific to the exhaustive markers expressed on tumor CD8+ T-cells ex vivo in order to improve cytokine release and cytotoxic function in comparison to two control groups: (1.) T-cells that receive no antibodies; (2.) T-cells...

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Detalles Bibliográficos
Autores principales: Krumeich, Lauren Norell, Akimova, Tatiana, Stadanlick, Jason, Rao, Abhishek, Sullivan, Neil, Concors, Seth, Hernandez, Paul, Aufhauser, David, Eruslanov, Evgeniy, Hancock, Wayne, Levine, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2019
Materias:
Basic/Translational Science/Team Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799098/
http://dx.doi.org/10.1017/cts.2019.33

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