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3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement

OBJECTIVES/SPECIFIC AIMS: The aim of the present study is to explore the relationships between resilience, pain catastrophizing, and functional outcomes in pre-and post-operative TKR patients. The primary outcome is the ability of the Brief Resilience Scale (BRS) to predict function using the Knee i...

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Autores principales: Nwankwo, Vesta, Jiranek, William, George, Steven, Bettger, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799136/
http://dx.doi.org/10.1017/cts.2019.271
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author Nwankwo, Vesta
Jiranek, William
George, Steven
Bettger, Janet
author_facet Nwankwo, Vesta
Jiranek, William
George, Steven
Bettger, Janet
author_sort Nwankwo, Vesta
collection PubMed
description OBJECTIVES/SPECIFIC AIMS: The aim of the present study is to explore the relationships between resilience, pain catastrophizing, and functional outcomes in pre-and post-operative TKR patients. The primary outcome is the ability of the Brief Resilience Scale (BRS) to predict function using the Knee injury and Osteoarthritis Outcome Score Joint Replacement (KOOS, JR.) and overall health on the Patient-Reported Outcome Measurement Information System Global Health (PROMIS GH). METHODS/STUDY POPULATION: Recruited patients will provide informed consent during in-person office visits. At the pre-surgery intake appointment, patients will provide demographic information and complete baseline questionnaires assessing resilience, pain catastrophizing, knee stiffness, pain, and function, and impression of overall health. In-person or electronic follow-up assessments will be administered post-surgery at 6-week, 3-month, and 6-month appointments. RESULTS/ANTICIPATED RESULTS: We aim to recruit 150 patients for this study. We do not expect a difference in sociodemographic characteristics of the patient sample. P-values will be based on t-tests and correlations calculated by comparing only non-missing values. Each outcome measure will be examined at each time point and trajectories will be calculated to determine the change in each outcome over time. Using latent class growth modeling we will examine individual change over time for each outcome (BRS, PCS, PROMIS GH, and KOOS JR.), and the association of resilience and pain with change in function (KOOS, JR. total score) and overall health (PROMIS GH). DISCUSSION/SIGNIFICANCE OF IMPACT: To our knowledge, this is the only known study that will compare resilience, pain catastrophizing and longitudinal health outcomes in a single paradigm. Results will hopefully inform the design and implementation of future studies that will assess the impact of preoperative treatment of vulnerable patients. The ultimate goal is to improve functional recovery by using pre-identified psychological constructs as intervention points. Ideally, the same measures would be implemented, however, details of this plan will be established following completion of this study.
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spelling pubmed-67991362019-10-28 3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement Nwankwo, Vesta Jiranek, William George, Steven Bettger, Janet J Clin Transl Sci Science and Health Policy/Ethics/Health Impacts/Outcomes Research OBJECTIVES/SPECIFIC AIMS: The aim of the present study is to explore the relationships between resilience, pain catastrophizing, and functional outcomes in pre-and post-operative TKR patients. The primary outcome is the ability of the Brief Resilience Scale (BRS) to predict function using the Knee injury and Osteoarthritis Outcome Score Joint Replacement (KOOS, JR.) and overall health on the Patient-Reported Outcome Measurement Information System Global Health (PROMIS GH). METHODS/STUDY POPULATION: Recruited patients will provide informed consent during in-person office visits. At the pre-surgery intake appointment, patients will provide demographic information and complete baseline questionnaires assessing resilience, pain catastrophizing, knee stiffness, pain, and function, and impression of overall health. In-person or electronic follow-up assessments will be administered post-surgery at 6-week, 3-month, and 6-month appointments. RESULTS/ANTICIPATED RESULTS: We aim to recruit 150 patients for this study. We do not expect a difference in sociodemographic characteristics of the patient sample. P-values will be based on t-tests and correlations calculated by comparing only non-missing values. Each outcome measure will be examined at each time point and trajectories will be calculated to determine the change in each outcome over time. Using latent class growth modeling we will examine individual change over time for each outcome (BRS, PCS, PROMIS GH, and KOOS JR.), and the association of resilience and pain with change in function (KOOS, JR. total score) and overall health (PROMIS GH). DISCUSSION/SIGNIFICANCE OF IMPACT: To our knowledge, this is the only known study that will compare resilience, pain catastrophizing and longitudinal health outcomes in a single paradigm. Results will hopefully inform the design and implementation of future studies that will assess the impact of preoperative treatment of vulnerable patients. The ultimate goal is to improve functional recovery by using pre-identified psychological constructs as intervention points. Ideally, the same measures would be implemented, however, details of this plan will be established following completion of this study. Cambridge University Press 2019-03-27 /pmc/articles/PMC6799136/ http://dx.doi.org/10.1017/cts.2019.271 Text en © The Association for Clinical and Translational Science 2019 http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-ncnd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
spellingShingle Science and Health Policy/Ethics/Health Impacts/Outcomes Research
Nwankwo, Vesta
Jiranek, William
George, Steven
Bettger, Janet
3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement
title 3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement
title_full 3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement
title_fullStr 3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement
title_full_unstemmed 3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement
title_short 3196 Assessing the Relationship between Resilience and Pain Catastrophizing in Patient Reported Outcomes following Total Knee Replacement
title_sort 3196 assessing the relationship between resilience and pain catastrophizing in patient reported outcomes following total knee replacement
topic Science and Health Policy/Ethics/Health Impacts/Outcomes Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799136/
http://dx.doi.org/10.1017/cts.2019.271
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