2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy

OBJECTIVES/SPECIFIC AIMS: Objectives: To determine genes that are shared between human and obese Zucker rat hypertrophic hearts, in order to identify potential early biomarkers and drug target for heart failure. METHODS/STUDY POPULATION: Four age-paired lean and obese Zucker rats were used. The huma...

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Detalles Bibliográficos
Autores principales: Newman, Mackenzie, Stricker, Janelle, Yu, Han-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Basic/Translational Science/Team Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799189/
http://dx.doi.org/10.1017/cts.2018.71
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author Newman, Mackenzie
Stricker, Janelle
Yu, Han-Gang
author_facet Newman, Mackenzie
Stricker, Janelle
Yu, Han-Gang
author_sort Newman, Mackenzie
collection PubMed
description OBJECTIVES/SPECIFIC AIMS: Objectives: To determine genes that are shared between human and obese Zucker rat hypertrophic hearts, in order to identify potential early biomarkers and drug target for heart failure. METHODS/STUDY POPULATION: Four age-paired lean and obese Zucker rats were used. The human data are derived from doi:10.1152/physiolgenomics.00122.2016. RESULTS/ANTICIPATED RESULTS: We expect to find genes that are upregulated and downregulated in Zucker rats and humans that present cardiac hypertrophy. DISCUSSION/SIGNIFICANCE OF IMPACT: The genes and proteins determined from this study will provide future directions in order to determine whether obese Zucker rats are a valid model organism for the development of cardiac hypertrophy.
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spelling pubmed-67991892019-10-28 2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy Newman, Mackenzie Stricker, Janelle Yu, Han-Gang J Clin Transl Sci Basic/Translational Science/Team Science OBJECTIVES/SPECIFIC AIMS: Objectives: To determine genes that are shared between human and obese Zucker rat hypertrophic hearts, in order to identify potential early biomarkers and drug target for heart failure. METHODS/STUDY POPULATION: Four age-paired lean and obese Zucker rats were used. The human data are derived from doi:10.1152/physiolgenomics.00122.2016. RESULTS/ANTICIPATED RESULTS: We expect to find genes that are upregulated and downregulated in Zucker rats and humans that present cardiac hypertrophy. DISCUSSION/SIGNIFICANCE OF IMPACT: The genes and proteins determined from this study will provide future directions in order to determine whether obese Zucker rats are a valid model organism for the development of cardiac hypertrophy. Cambridge University Press 2018-11-21 /pmc/articles/PMC6799189/ http://dx.doi.org/10.1017/cts.2018.71 Text en © The Association for Clinical and Translational Science 2018 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic/Translational Science/Team Science
Newman, Mackenzie
Stricker, Janelle
Yu, Han-Gang
2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy
title 2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy
title_full 2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy
title_fullStr 2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy
title_full_unstemmed 2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy
title_short 2060 Exploring gene expression signature shared between obese Zucker rat and human cardiac hypertrophy
title_sort 2060 exploring gene expression signature shared between obese zucker rat and human cardiac hypertrophy
topic Basic/Translational Science/Team Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799189/
http://dx.doi.org/10.1017/cts.2018.71
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AT yuhangang 2060exploringgeneexpressionsignaturesharedbetweenobesezuckerratandhumancardiachypertrophy

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