Cargando…

2018 Synaptic vesicle 2 receptors as a novel targets for neuroendocrine cancer therapy

OBJECTIVES/SPECIFIC AIMS: (1) To delineate the function of the heavy-chain receptor binding domain (HCR), a portion of botulinum neurotoxin type A (BoNT/A) and synaptic vesicle 2 (SV2) signaling pathway, which provide a novel multipurpose biologic with potential clinical applications in tumor detect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaskula-Sztul, Renata, Whitt, Jason D., Ou, Jianfa, Liu, Margaret X., Aburjania, Zviadi, Chen, Herbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2018
Materias:	Basic/Translational Science/Team Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799207/ http://dx.doi.org/10.1017/cts.2018.125

Ejemplares similares

Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells
por: Aburjania, Zviadi, et al.
Publicado: (2020)

Ex Vivo Modeling of Human Neuroendocrine Tumors in Tissue Surrogates
por: Herring, Brendon, et al.
Publicado: (2021)

Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growth in vivo
por: Jang, Samuel, et al.
Publicado: (2017)

3249 Defining the Extracellular Vesicle Content of Interstitial Fluid for Blood-Free Diagnostics; Extraction Methods and Initial Characterization
por: Robert Taylor, Justin Baca, et al.
Publicado: (2019)

3212 Development of a Contractile Fontan Circuit to Decrease Central Venous Pressures in Single Ventricle Patients
por: Ferrari, Margaret Rose, et al.
Publicado: (2019)

3348 Structural Determinants of Neoantigen Immunogenicity for Cancer Therapy
por: Devlin, Jason, et al.
Publicado: (2019)

2286 A CTSA External Reviewer Exchange Consortium: Description and lessons learned
por: Schneider, Margaret, et al.
Publicado: (2018)

2429 Optogenetic stimulation of corticotropin-releasing hormone expressing neurons in Barrington’s nucleus recapitulates the social stress voiding phenotype in mice
por: Van Batavia, Jason, et al.
Publicado: (2018)

2345 An electronic roadmap to customized human research training plans
por: Maas, Jennifer, et al.
Publicado: (2018)

3005 Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome
por: Sule, Gautam, et al.
Publicado: (2019)

3300 Progesterone receptor alters lipid biology in luminal breast cancer
por: Ward, Ashley Vanessa, et al.
Publicado: (2019)

3582 Scavenger Receptor Expression is Differentially Affected by DNAzyme-Gold Nanoparticle Conjugates
por: Sylber, Cory, et al.
Publicado: (2019)

3343 Identification of host-microbial interaction networks that mediate intestinal epithelial barrier function in necrotizing enterocolitis
por: Hill, David R, et al.
Publicado: (2019)

2213 Tumor suppressors p53 and ARF control oncogenic potential of triple-negative breast cancer cells by regulating RNA editing enzyme ADAR1
por: Kung, Che-Pei, et al.
Publicado: (2018)

2527 Mount Sinai health hackathon: Harnessing the power of collaboration to advance experiential team science education
por: Gabrilove, Janice Lynn, et al.
Publicado: (2018)

3174 Tumor suppressors p53 and ARF control oncogenic potential of triple-negative breast cancer cells by regulating RNA editing enzyme ADAR1
por: Kung, Che-Pei, et al.
Publicado: (2019)

2185 The effects of autoimmune inflammation on proliferation, differentiation, and androgen receptor signaling in adult prostate stem cells
por: Cooper, Paula, et al.
Publicado: (2018)

3236 Identification of exhaustive markers in cytotoxic T-cells to guide immune modulation in hepatocellular carcinoma ex vivo
por: Krumeich, Lauren Norell, et al.
Publicado: (2019)

2297 The direct effect of trimethylamine N-oxide (TMAO) on cardiac muscle contractile mechanics
por: Oakley, Carlee I., et al.
Publicado: (2018)

2181 Age-related change in 5-HT6 receptor availability in healthy male volunteers measured with 11C-GSK215083 PET
por: Radhakrishnan, Rajiv, et al.
Publicado: (2018)

3533 Delayed Administration Of Angiotensin Receptor (AT2R) Agonist C21 Downregulates Diabetes Induced Pro-Inflammatory Microglia Activation To Improve Cognitive & Functional Recovery Post Stroke: Therapeutic Indications For The Treatment Of Vascular Cognitive
por: Jackson, Ladonya, et al.
Publicado: (2019)

2325 Targeting isoform-specific PI3 kinase signaling for treatment of cutaneous T cell lymphoma
por: Raychaudhuri, Suravi, et al.
Publicado: (2018)

3293 Region Specific Dysregulation of Dopaminergic Signaling in Mice Displaying Excessive Over-Grooming
por: Foster, Daniel, et al.
Publicado: (2019)

2167 Beyond diagnosis: Using ultrasound to affect tumor vasculature for hepatocellular carcinoma (HCC) therapy
por: D’Souza, Julia, et al.
Publicado: (2018)

2243 Perceptions of translational science among faculty researchers: A survey to inform the efforts of a multidisciplinary education and research program
por: Devi, Gayathri, et al.
Publicado: (2018)

2563 National dissemination of the accrual to clinical trials (ACT) network across the Clinical and Translational Science Award (CTSA) Consortium*
por: Morrato, Elaine H., et al.
Publicado: (2018)

3152 The role of myostatin in diabetic bone disease
por: Kalaitzoglou, Evangelia, et al.
Publicado: (2019)

3504 Metagenomic characterization of influenza virus: bacteria super-infections associated with death and survival
por: Klonoski, Josh, et al.
Publicado: (2019)

2041 The cell-cell adhesion component PLEKHA7 regulates the pro-tumorigenic MIR17HG long non-coding RNA in colon epithelial cells
por: Bridges, Mary C., et al.
Publicado: (2018)

2280 Subjective, physiological activation and habituation, and response to written trauma narrative exposure
por: Howell, Mary K., et al.
Publicado: (2018)

2420 Examining characteristics of placebo effects on trauma-related insomnia in a suvorexant trial
por: Uweh, Kimberly
Publicado: (2018)

2281 Prophylactic broad-spectrum antibiotics for childhood malnutrition
por: Langdon, Amy Elizabeth, et al.
Publicado: (2018)

2385 Role of the antioxidant enzyme catalase in respiratory syncytial virus infection
por: Ansar, Maria, et al.
Publicado: (2018)

2448 The effect of allopurinol on pediatric patients undergoing maintenance chemotherapy for acute lymphoblastic leukemia or lymphoblastic lymphoma
por: Bhuiyan, Mariam M., et al.
Publicado: (2018)

2153 The plasma contact system and its role in common variable immunodeficiency (CVID): An explorative study
por: Smith, Tukisa, et al.
Publicado: (2018)

3114 Investigating the therapeutic potential of parthenolide in the treatment of hematopoietic neoplasms in dogs
por: Schlein, Lisa J, et al.
Publicado: (2019)

2128 Using real-time functional magnetic resonance imaging (fMRI) neurofeedback as a tool for demonstrating therapeutic efficacy in cognitive behavioral therapy
por: Dickerson, Kathryn, et al.
Publicado: (2018)

3128 Copula-Based Regression Models for Correlated Bivariate Binary Outcomes: Application to Ophthalmologic Data Structures
por: Alqahtani, Haifa, et al.
Publicado: (2019)

2190 Longitudinal changes in EEG power envelope connectivity are proportional to motor recovery in chronic stroke patients
por: Humphries, Joseph B., et al.
Publicado: (2018)

2165 Vesicular secretion of suppressor of cytokine signaling 3 by alveolar macrophages is dysregulated in NSCLC patients and its provision inhibits epithelial cell transformation and tumor cell function
por: Speth, Jennifer, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1pg86ibqi4c5ieeghqpmuet6n6