Cargando…

2203: Engraftment and gene expression of an HIV resistant immune system in a Phase I trial of an HIV stem cell gene therapy strategy

OBJECTIVES/SPECIFIC AIMS: To date, only 1 documented case of an individual cured of HIV has been reported. He received an allogeneic bone marrow transplant with cells harboring an HIV-resistant genotype. To mimic this result, we have initiated a Phase I to evaluate the safety of an autologous stem c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anderson, Joseph, Hendrix, Kyle, Beegle, Julie, Nolta, Jan A., Abedi, Mehrdad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2018
Materias:	Clinical Trial
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799239/ http://dx.doi.org/10.1017/cts.2017.120

Ejemplares similares

PReS-FINAL-2203: Assessment of sleep problems in children with familial Mediterranean fever
por: Makay, B, et al.
Publicado: (2013)

Population pharmacokinetics of dolutegravir in HIV-infected treatment-naive patients
por: Zhang, Jianping, et al.
Publicado: (2015)

Pharmacokinetics of dolutegravir in HIV-seronegative subjects with severe renal impairment
por: Weller, Stephen, et al.
Publicado: (2013)

Identification of Hematopoietic Stem Cell Engraftment Genes in Gene Therapy Studies
por: Powers, John M, et al.
Publicado: (2013)

PB2203: AGEING OF LONG-TERM ALLOGENEIC HEMATOPOIETIC CELLS RECIPIENTS COMPARED TO THEIR DONORS
por: Czarnogórski, M., et al.
Publicado: (2022)

PB2203: INCIDENCE AND PREVALENCE OF MYELOFIBROSIS IN GERMANY: A RETROSPECTIVE CLAIMS DATA ANALYSIS
por: Junker, Sophia, et al.
Publicado: (2023)

Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir
por: Song, Ivy, et al.
Publicado: (2014)

2203. Risk Factors for Hepatitis C in Western Africa: An Observational Study in a STI Clinic
por: Akyar, Eda, et al.
Publicado: (2018)

Phase I study of liposomal irinotecan in patients with metastatic breast cancer: findings from the expansion phase
por: Sachdev, Jasgit C., et al.
Publicado: (2020)

Phase I trial to investigate the effect of renal impairment on isavuconazole pharmacokinetics
por: Townsend, Robert W., et al.
Publicado: (2017)

Efficacy of stem cell therapy in ambulatory and nonambulatory children with Duchenne muscular dystrophy – Phase I–II
por: Dai, Alper, et al.
Publicado: (2018)

Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells
por: Ratajczak, Mariusz Z., et al.
Publicado: (2015)

Improving Islet Engraftment by Gene Therapy
por: Wang, Xiaojie, et al.
Publicado: (2011)

Adherence to HAART therapy measured by electronic monitoring in newly diagnosed HIV patients in Botswana
por: Vriesendorp, Reinout, et al.
Publicado: (2007)

Topical administration of regorafenib eye drops: phase I dose‐escalation study in healthy volunteers
por: Zimmermann, Torsten, et al.
Publicado: (2018)

A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints
por: Mozgunov, Pavel, et al.
Publicado: (2019)

Epidemiology of Injuries Identified at the NFL Scouting Combine and Their Impact on Performance in the National Football League: Evaluation of 2203 Athletes From 2009 to 2015
por: Beaulieu-Jones, Brendin R., et al.
Publicado: (2017)

ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer
por: Wilson, James M., et al.
Publicado: (2016)

Prevention of atherosclerosis in patients living with HIV
por: De Lorenzo, Ferruccio, et al.
Publicado: (2009)

Assessing in vitro stem-cell function and tracking engraftment of stem cells in ischaemic hearts by using novel iRFP gene labelling
por: Wang, Yingjie, et al.
Publicado: (2014)

Higher rate of progression in HIV(–) than in HIV(+) patients after rituximab for HHV8(+) multicentric Castleman disease
por: Rasmussen, Camille, et al.
Publicado: (2023)

Safety, pharmacodynamic, and pharmacokinetic characterization of vericiguat: results from six phase I studies in healthy subjects
por: Boettcher, Michael, et al.
Publicado: (2020)

Phase I/II randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke
por: Tsang, Kam Sze, et al.
Publicado: (2017)

Effects of Pegylated Interferon/Ribavirin on Bone Turnover Markers in HIV/Hepatitis C Virus-Coinfected Patients
por: Bedimo, Roger, et al.
Publicado: (2016)

Association of baseline ROR1 and ROR2 gene expression with clinical outcomes in the I-SPY2 neoadjuvant breast cancer trial
por: Parker, Barbara A., et al.
Publicado: (2023)

Phase I trial to evaluate the addition of alisertib to fulvestrant in women with endocrine-resistant, ER+ metastatic breast cancer
por: Haddad, Tufia C., et al.
Publicado: (2017)

Changes in Bone Turnover and Bone Loss in HIV-Infected Patients Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine
por: Haskelberg, Hila, et al.
Publicado: (2012)

Safety and Efficacy of FIT039 for Verruca Vulgaris: A Placebo-Controlled, Phase I/II Randomized Controlled Trial
por: Nomura, Takashi, et al.
Publicado: (2021)

A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma
por: Metselaar, Josbert, et al.
Publicado: (2023)

2203. Patient-Specific Risk Stratification to Identify Patients at High and Low Risk for P. aeruginosa in Community-Acquired Pneumonia
por: Justin Moore, William, et al.
Publicado: (2019)

Whole genome sequence of Mycoplasma ovipneumoniae strain NXNK2203 isolated from Hu sheep in Ningxia province, China
por: Wang, Jiandong, et al.
Publicado: (2023)

Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt
por: Mitsuyasu, Ronald T., et al.
Publicado: (2011)

CALIBER: a phase II randomized feasibility trial of chemoablation with mitomycin‐C vs surgical management in low‐risk non‐muscle‐invasive bladder cancer
por: Mostafid, A. Hugh, et al.
Publicado: (2020)

Ultra‐hypofractionated radiation therapy for unfavourable intermediate‐risk and high‐risk prostate cancer is safe and effective: 5‐year outcomes of a phase II trial
por: Macias, Victor A., et al.
Publicado: (2019)

Brain HIV-1 latently-infected reservoirs targeted by the suicide gene strategy
por: Saeb, Sepideh, et al.
Publicado: (2021)

Marrow Stem Cells Shift Gene Expression and Engraftment Phenotype with Cell Cycle Transit
por: Lambert, Jean-François, et al.
Publicado: (2003)

Mobilization-based chemotherapy-free engraftment of gene-edited human hematopoietic stem cells
por: Omer-Javed, Attya, et al.
Publicado: (2022)

Cardiac effects of amiselimod compared with fingolimod and placebo: results of a randomised, parallel‐group, phase I study in healthy subjects
por: Harada, Tomohiko, et al.
Publicado: (2017)

Activity of preclinical and phase I clinical trial of a novel androgen receptor antagonist GT0918 in metastatic breast cancer
por: Li, Huiping, et al.
Publicado: (2021)

Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice
por: Bella, Ramona, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6r779pv2fvs6etu0j0jdndtbbj