2003 Mixed meal effects of neprilysin inhibition

OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/...

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Detalles Bibliográficos
Autores principales: Wilson, Jessica R., Rader, Daniel, Townsend, Raymond, Rickels, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Basic/Translational Science/Team Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799458/
http://dx.doi.org/10.1017/cts.2018.171
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author Wilson, Jessica R.
Rader, Daniel
Townsend, Raymond
Rickels, Michael
author_facet Wilson, Jessica R.
Rader, Daniel
Townsend, Raymond
Rickels, Michael
author_sort Wilson, Jessica R.
collection PubMed
description OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/ANTICIPATED RESULTS: We anticipate higher intact GLP-1 area under the cure after the meal when subjects receive sacubitril/valsartan compared with valsartan. DISCUSSION/SIGNIFICANCE OF IMPACT: Neprilysin inhibition may be a target for anti-diabetes therapy by decreasing degradation of GLP-1.
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spelling pubmed-67994582019-10-28 2003 Mixed meal effects of neprilysin inhibition Wilson, Jessica R. Rader, Daniel Townsend, Raymond Rickels, Michael J Clin Transl Sci Basic/Translational Science/Team Science OBJECTIVES/SPECIFIC AIMS: Test the hypothesis that neprilysin inhibition with sacubitril/valsartan will increase endogenous intact GLP-1 after a mixed meal compared with valsartan. METHODS/STUDY POPULATION: Adults 18–80 years with pre-diabetes or type 2 diabetes and elevated blood pressure. RESULTS/ANTICIPATED RESULTS: We anticipate higher intact GLP-1 area under the cure after the meal when subjects receive sacubitril/valsartan compared with valsartan. DISCUSSION/SIGNIFICANCE OF IMPACT: Neprilysin inhibition may be a target for anti-diabetes therapy by decreasing degradation of GLP-1. Cambridge University Press 2018-11-21 /pmc/articles/PMC6799458/ http://dx.doi.org/10.1017/cts.2018.171 Text en © The Association for Clinical and Translational Science 2018 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic/Translational Science/Team Science
Wilson, Jessica R.
Rader, Daniel
Townsend, Raymond
Rickels, Michael
2003 Mixed meal effects of neprilysin inhibition
title 2003 Mixed meal effects of neprilysin inhibition
title_full 2003 Mixed meal effects of neprilysin inhibition
title_fullStr 2003 Mixed meal effects of neprilysin inhibition
title_full_unstemmed 2003 Mixed meal effects of neprilysin inhibition
title_short 2003 Mixed meal effects of neprilysin inhibition
title_sort 2003 mixed meal effects of neprilysin inhibition
topic Basic/Translational Science/Team Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799458/
http://dx.doi.org/10.1017/cts.2018.171
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