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2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation

OBJECTIVES/SPECIFIC AIMS: To identify cardiac structural and function parameters, obtained on usual stroke-care TTE evaluation, associated with cardioembolic stroke (CE) in patients without AF. Hypothesis—left atrial (LA) size and valve dysfunction will be strongly associated with incident CE. METHO...

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Autores principales: Johansen, Michelle C., Williams, Nicole L., Gottesman, Rebecca F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799505/
http://dx.doi.org/10.1017/cts.2018.47
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author Johansen, Michelle C.
Williams, Nicole L.
Gottesman, Rebecca F.
author_facet Johansen, Michelle C.
Williams, Nicole L.
Gottesman, Rebecca F.
author_sort Johansen, Michelle C.
collection PubMed
description OBJECTIVES/SPECIFIC AIMS: To identify cardiac structural and function parameters, obtained on usual stroke-care TTE evaluation, associated with cardioembolic stroke (CE) in patients without AF. Hypothesis—left atrial (LA) size and valve dysfunction will be strongly associated with incident CE. METHODS/STUDY POPULATION: Inclusion criteria: July 1, 2013 to July 1, 2015 admission with imaging-confirmed ischemic stroke, no AF, TTE within 1st 7 days. TTE structure/function parameters were recorded. Stroke subtype (CE vs. other) defined using TOAST criteria, blinded to TTE. New AF definition: AF on ECG, telemetry or event monitor. CE/New AF outcome of interest in separate multivariable logistic regression models testing associations with TTE parameters (adjusting for demographics/vascular risk factors). RESULTS/ANTICIPATED RESULTS: Participants (n=332) were ~60 years hypertensive black males with moderate NIHSS and normal ejection fraction. In adjusted models, odds of CE increased with increasing LA systolic diameter (per 0.1 cm), mitral E point velocity(cm/s), mitral valve dysfunction, wall motion abnormality. New AF also associated with increasing LA systolic diameter. DISCUSSION/SIGNIFICANCE OF IMPACT: These findings may suggest cardiac structural changes independent of AF that are on the CE causal pathway. Understanding the relationship between such TTE parameters and stroke subtype would impact clinical practice, as such TTE data is underutilized when considering stroke mechanism and management.
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spelling pubmed-67995052019-10-28 2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation Johansen, Michelle C. Williams, Nicole L. Gottesman, Rebecca F. J Clin Transl Sci Basic/Translational Science/Team Science OBJECTIVES/SPECIFIC AIMS: To identify cardiac structural and function parameters, obtained on usual stroke-care TTE evaluation, associated with cardioembolic stroke (CE) in patients without AF. Hypothesis—left atrial (LA) size and valve dysfunction will be strongly associated with incident CE. METHODS/STUDY POPULATION: Inclusion criteria: July 1, 2013 to July 1, 2015 admission with imaging-confirmed ischemic stroke, no AF, TTE within 1st 7 days. TTE structure/function parameters were recorded. Stroke subtype (CE vs. other) defined using TOAST criteria, blinded to TTE. New AF definition: AF on ECG, telemetry or event monitor. CE/New AF outcome of interest in separate multivariable logistic regression models testing associations with TTE parameters (adjusting for demographics/vascular risk factors). RESULTS/ANTICIPATED RESULTS: Participants (n=332) were ~60 years hypertensive black males with moderate NIHSS and normal ejection fraction. In adjusted models, odds of CE increased with increasing LA systolic diameter (per 0.1 cm), mitral E point velocity(cm/s), mitral valve dysfunction, wall motion abnormality. New AF also associated with increasing LA systolic diameter. DISCUSSION/SIGNIFICANCE OF IMPACT: These findings may suggest cardiac structural changes independent of AF that are on the CE causal pathway. Understanding the relationship between such TTE parameters and stroke subtype would impact clinical practice, as such TTE data is underutilized when considering stroke mechanism and management. Cambridge University Press 2018-11-21 /pmc/articles/PMC6799505/ http://dx.doi.org/10.1017/cts.2018.47 Text en © The Association for Clinical and Translational Science 2018 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Basic/Translational Science/Team Science
Johansen, Michelle C.
Williams, Nicole L.
Gottesman, Rebecca F.
2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation
title 2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation
title_full 2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation
title_fullStr 2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation
title_full_unstemmed 2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation
title_short 2386 Associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation
title_sort 2386 associations of transthoracic echocardiographic features with cardioembolic stroke among patients without atrial fibrillation
topic Basic/Translational Science/Team Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799505/
http://dx.doi.org/10.1017/cts.2018.47
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