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The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

Glioma and cerebral ischemic stroke are two major events that lead to patient death worldwide. Although these conditions have different physiological incidences, ~10% of ischemic stroke patients develop cerebral cancer, especially glioma, in the postischemic stages. Additionally, the high proliferat...

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Autores principales: Ghosh, Mrinal K., Chakraborty, Dipankar, Sarkar, Sibani, Bhowmik, Arijit, Basu, Malini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799849/
https://www.ncbi.nlm.nih.gov/pubmed/31637020
http://dx.doi.org/10.1038/s41392-019-0075-4
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author Ghosh, Mrinal K.
Chakraborty, Dipankar
Sarkar, Sibani
Bhowmik, Arijit
Basu, Malini
author_facet Ghosh, Mrinal K.
Chakraborty, Dipankar
Sarkar, Sibani
Bhowmik, Arijit
Basu, Malini
author_sort Ghosh, Mrinal K.
collection PubMed
description Glioma and cerebral ischemic stroke are two major events that lead to patient death worldwide. Although these conditions have different physiological incidences, ~10% of ischemic stroke patients develop cerebral cancer, especially glioma, in the postischemic stages. Additionally, the high proliferation, venous thrombosis and hypercoagulability of the glioma mass increase the significant risk of thromboembolism, including ischemic stroke. Surprisingly, these events share several common pathways, viz. hypoxia, cerebral inflammation, angiogenesis, etc., but the proper mechanism behind this co-occurrence has yet to be discovered. The hypercoagulability and presence of the D-dimer level in stroke are different in cancer patients than in the noncancerous population. Other factors such as atherosclerosis and coagulopathy involved in the pathogenesis of stroke are partially responsible for cancer, and the reverse is also partially true. Based on clinical and neurosurgical experience, the neuronal structures and functions in the brain and spine are observed to change after a progressive attack of ischemia that leads to hypoxia and atrophy. The major population of cancer cells cannot survive in an adverse ischemic environment that excludes cancer stem cells (CSCs). Cancer cells in stroke patients have already metastasized, but early-stage cancer patients also suffer stroke for multiple reasons. Therefore, stroke is an early manifestation of cancer. Stroke and cancer share many factors that result in an increased risk of stroke in cancer patients, and vice-versa. The intricate mechanisms for stroke with and without cancer are different. This review summarizes the current clinical reports, pathophysiology, probable causes of co-occurrence, prognoses, and treatment possibilities.
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spelling pubmed-67998492019-10-21 The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports Ghosh, Mrinal K. Chakraborty, Dipankar Sarkar, Sibani Bhowmik, Arijit Basu, Malini Signal Transduct Target Ther Review Article Glioma and cerebral ischemic stroke are two major events that lead to patient death worldwide. Although these conditions have different physiological incidences, ~10% of ischemic stroke patients develop cerebral cancer, especially glioma, in the postischemic stages. Additionally, the high proliferation, venous thrombosis and hypercoagulability of the glioma mass increase the significant risk of thromboembolism, including ischemic stroke. Surprisingly, these events share several common pathways, viz. hypoxia, cerebral inflammation, angiogenesis, etc., but the proper mechanism behind this co-occurrence has yet to be discovered. The hypercoagulability and presence of the D-dimer level in stroke are different in cancer patients than in the noncancerous population. Other factors such as atherosclerosis and coagulopathy involved in the pathogenesis of stroke are partially responsible for cancer, and the reverse is also partially true. Based on clinical and neurosurgical experience, the neuronal structures and functions in the brain and spine are observed to change after a progressive attack of ischemia that leads to hypoxia and atrophy. The major population of cancer cells cannot survive in an adverse ischemic environment that excludes cancer stem cells (CSCs). Cancer cells in stroke patients have already metastasized, but early-stage cancer patients also suffer stroke for multiple reasons. Therefore, stroke is an early manifestation of cancer. Stroke and cancer share many factors that result in an increased risk of stroke in cancer patients, and vice-versa. The intricate mechanisms for stroke with and without cancer are different. This review summarizes the current clinical reports, pathophysiology, probable causes of co-occurrence, prognoses, and treatment possibilities. Nature Publishing Group UK 2019-10-12 /pmc/articles/PMC6799849/ /pubmed/31637020 http://dx.doi.org/10.1038/s41392-019-0075-4 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Ghosh, Mrinal K.
Chakraborty, Dipankar
Sarkar, Sibani
Bhowmik, Arijit
Basu, Malini
The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
title The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
title_full The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
title_fullStr The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
title_full_unstemmed The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
title_short The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
title_sort interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799849/
https://www.ncbi.nlm.nih.gov/pubmed/31637020
http://dx.doi.org/10.1038/s41392-019-0075-4
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