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Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China
Cerebrospinal fluid (CSF) protein values decline over the first few months of life as the infant's blood-CSF barrier matures. However, published studies have not reported CSF protein reference values of Chinese infants and differ in the reported rate, timing, and magnitude of this decline. The...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799853/ https://www.ncbi.nlm.nih.gov/pubmed/31593118 http://dx.doi.org/10.1097/MD.0000000000017500 |
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author | Liu, Zhigang Jia, Deqin Dai, Jieming Zhou, Xing Qin, Zhoulian Chen, Liang Zhang, Jieyan Chen, Guohua He, Xiaocheng Wan, Ruipin Ye, Xingguang |
author_facet | Liu, Zhigang Jia, Deqin Dai, Jieming Zhou, Xing Qin, Zhoulian Chen, Liang Zhang, Jieyan Chen, Guohua He, Xiaocheng Wan, Ruipin Ye, Xingguang |
author_sort | Liu, Zhigang |
collection | PubMed |
description | Cerebrospinal fluid (CSF) protein values decline over the first few months of life as the infant's blood-CSF barrier matures. However, published studies have not reported CSF protein reference values of Chinese infants and differ in the reported rate, timing, and magnitude of this decline. The objective of this study was to determine reference intervals for CSF protein using available data of children in southern China. This retrospective study included infants who had a lumbar puncture (LP) performed in the Department of Pediatrics of Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan of an urban tertiary care children's hospital between January 1, 2008 and May 31, 2018. Infants with conditions suspected or known to cause elevated CSF protein concentrations were excluded. Of 3712 infants undergoing LP, 1043 (28.1%) met inclusion criteria. Results showed that there is an age-related decline in CSF protein concentration. The median CSF protein value was 62 mg/dL [interquartile range (IQR): 47–81 mg/dL] in infants aged 0 to 56 days (group 1). The 95th percentile values were 116 mg/dL for infants 0 to 28 days and 80 mg/dL for infants 29 to 56 days. The 95th percentile values by age category were as follows: ages 0 to 14 days, 117 mg/dL; ages 15 to 28 days, 107 mg/dL; ages 29 to 42 days, 96 mg/dL; and ages 43 to 56 days, 74 mg/dL. The median CSF protein value was 21 mg/dL (IQR: 16–31 mg/dL) in infants aged 2 months to <3 years (group 2). The 95th percentile values were 57 mg/dL for infants 2 to <6 months and 34 mg/dL for infants 6 to ≤24 months. The 95th percentile values by age category were as follows: ages 2 to <3 months, 66 mg/dL; ages 3 to <4 months, 52 mg/dL; ages 4 to <5 months, 53 mg/dL; and ages 5 to <6 months, 42 mg/dL. We quantify the age-related decline in CSF protein concentrations among infants 2 years of age and younger and provide age-specific reference values. The values reported here can be used to interpret the results of LP in infants ≤2 years of age. |
format | Online Article Text |
id | pubmed-6799853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-67998532019-11-18 Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China Liu, Zhigang Jia, Deqin Dai, Jieming Zhou, Xing Qin, Zhoulian Chen, Liang Zhang, Jieyan Chen, Guohua He, Xiaocheng Wan, Ruipin Ye, Xingguang Medicine (Baltimore) 3700 Cerebrospinal fluid (CSF) protein values decline over the first few months of life as the infant's blood-CSF barrier matures. However, published studies have not reported CSF protein reference values of Chinese infants and differ in the reported rate, timing, and magnitude of this decline. The objective of this study was to determine reference intervals for CSF protein using available data of children in southern China. This retrospective study included infants who had a lumbar puncture (LP) performed in the Department of Pediatrics of Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan of an urban tertiary care children's hospital between January 1, 2008 and May 31, 2018. Infants with conditions suspected or known to cause elevated CSF protein concentrations were excluded. Of 3712 infants undergoing LP, 1043 (28.1%) met inclusion criteria. Results showed that there is an age-related decline in CSF protein concentration. The median CSF protein value was 62 mg/dL [interquartile range (IQR): 47–81 mg/dL] in infants aged 0 to 56 days (group 1). The 95th percentile values were 116 mg/dL for infants 0 to 28 days and 80 mg/dL for infants 29 to 56 days. The 95th percentile values by age category were as follows: ages 0 to 14 days, 117 mg/dL; ages 15 to 28 days, 107 mg/dL; ages 29 to 42 days, 96 mg/dL; and ages 43 to 56 days, 74 mg/dL. The median CSF protein value was 21 mg/dL (IQR: 16–31 mg/dL) in infants aged 2 months to <3 years (group 2). The 95th percentile values were 57 mg/dL for infants 2 to <6 months and 34 mg/dL for infants 6 to ≤24 months. The 95th percentile values by age category were as follows: ages 2 to <3 months, 66 mg/dL; ages 3 to <4 months, 52 mg/dL; ages 4 to <5 months, 53 mg/dL; and ages 5 to <6 months, 42 mg/dL. We quantify the age-related decline in CSF protein concentrations among infants 2 years of age and younger and provide age-specific reference values. The values reported here can be used to interpret the results of LP in infants ≤2 years of age. Wolters Kluwer Health 2019-10-11 /pmc/articles/PMC6799853/ /pubmed/31593118 http://dx.doi.org/10.1097/MD.0000000000017500 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 3700 Liu, Zhigang Jia, Deqin Dai, Jieming Zhou, Xing Qin, Zhoulian Chen, Liang Zhang, Jieyan Chen, Guohua He, Xiaocheng Wan, Ruipin Ye, Xingguang Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China |
title | Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China |
title_full | Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China |
title_fullStr | Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China |
title_full_unstemmed | Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China |
title_short | Age-specific reference values for cerebrospinal fluid protein concentrations in children in southern China |
title_sort | age-specific reference values for cerebrospinal fluid protein concentrations in children in southern china |
topic | 3700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799853/ https://www.ncbi.nlm.nih.gov/pubmed/31593118 http://dx.doi.org/10.1097/MD.0000000000017500 |
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