Cargando…

Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study

BACKGROUND: The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance. METHODS AND FINDINGS: A phenome-wide association study (PheWAS...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xue, Meng, Xiangrui, He, Yazhou, Spiliopoulou, Athina, Timofeeva, Maria, Wei, Wei-Qi, Gifford, Aliya, Yang, Tian, Varley, Tim, Tzoulaki, Ioanna, Joshi, Peter, Denny, Joshua C., Mckeigue, Paul, Campbell, Harry, Theodoratou, Evropi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799886/ https://www.ncbi.nlm.nih.gov/pubmed/31626644 http://dx.doi.org/10.1371/journal.pmed.1002937

Ejemplares similares

Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank study
por: Meng, Xiangrui, et al.
Publicado: (2019)

MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank
por: Li, Xue, et al.
Publicado: (2018)

An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank
por: Li, Xue, et al.
Publicado: (2021)

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies
por: Li, Xue, et al.
Publicado: (2017)

Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank
por: Zhang, Xiaomeng, et al.
Publicado: (2021)

Physical activity and COVID-19: an observational and Mendelian randomisation study
por: Zhang, Xiaomeng, et al.
Publicado: (2020)

Mapping ICD-10 and ICD-10-CM Codes to Phecodes: Workflow Development and Initial Evaluation
por: Wu, Patrick, et al.
Publicado: (2019)

Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study
por: Zhou, Xuan, et al.
Publicado: (2022)

Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation
por: Yuan, Shuai, et al.
Publicado: (2022)

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials
por: Gill, Dipender, et al.
Publicado: (2020)

Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
por: Yuan, Shuai, et al.
Publicado: (2022)

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials
por: Theodoratou, Evropi, et al.
Publicado: (2014)

Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study
por: Zagkos, Loukas, et al.
Publicado: (2022)

Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study
por: He, Yazhou, et al.
Publicado: (2018)

Associations of genetically determined iron status across the phenome: A mendelian randomization study
por: Gill, Dipender, et al.
Publicado: (2019)

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
por: Shen, Xueyi, et al.
Publicado: (2020)

Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank
por: Horsfall, Laura J., et al.
Publicado: (2021)

Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies
por: Markozannes, Georgios, et al.
Publicado: (2020)

Bayesian methods for instrumental variable analysis with genetic instruments (‘Mendelian randomization’): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome
por: McKeigue, Paul M, et al.
Publicado: (2010)

Systematic meta-analyses and field synopsis of genetic and epigenetic studies in paediatric inflammatory bowel disease
por: Li, Xue, et al.
Publicado: (2016)

Instrumental Variable Estimation of the Causal Effect of Plasma 25-Hydroxy-Vitamin D on Colorectal Cancer Risk: A Mendelian Randomization Analysis
por: Theodoratou, Evropi, et al.
Publicado: (2012)

Phenome-wide heritability analysis of the UK Biobank
por: Ge, Tian, et al.
Publicado: (2017)

Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis
por: Zhou, Xuan, et al.
Publicado: (2022)

Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations, and clinical studies
por: Unlu, Gokhan, et al.
Publicado: (2020)

Biobanking across the phenome - at the center of chronic disease research
por: Imboden, Medea, et al.
Publicado: (2013)

Correction: Phenome-wide heritability analysis of the UK Biobank
por: Ge, Tian, et al.
Publicado: (2018)

Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance
por: He, Yazhou, et al.
Publicado: (2021)

Non‐genetic biomarkers and colorectal cancer risk: Umbrella review and evidence triangulation
por: Zhang, Xiaomeng, et al.
Publicado: (2020)

Validity of observational evidence on putative risk and protective factors: appraisal of 3744 meta-analyses on 57 topics
por: Janiaud, Perrine, et al.
Publicado: (2021)

Enhanced rare disease mapping for phenome-wide genetic association in the UK Biobank
por: Patrick, Matthew T., et al.
Publicado: (2022)

Appraising the causal role of risk factors in coronary artery disease and stroke: A systematic review of Mendelian Randomization studies
por: Georgiou, Andrea N, et al.
Publicado: (2023)

Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
por: Yuan, Shuai, et al.
Publicado: (2023)

Associations of Genetically Predicted Vitamin B(12) Status across the Phenome
por: Dib, Marie-Joe, et al.
Publicado: (2022)

The role of children in transmission of SARS-CoV-2: A rapid review
por: Li, Xue, et al.
Publicado: (2020)

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects
por: Gill, Dipender, et al.
Publicado: (2019)

Effects of common genetic variants associated with colorectal cancer risk on survival outcomes after diagnosis: A large population‐based cohort study
por: He, Yazhou, et al.
Publicado: (2019)

The Association of Dietary Intake of Purine-Rich Vegetables, Sugar-Sweetened Beverages and Dairy with Plasma Urate, in a Cross-Sectional Study
por: Zgaga, Lina, et al.
Publicado: (2012)

Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank
por: Gibson, Mark J., et al.
Publicado: (2023)

Iron Status and Risk of Stroke: A Mendelian Randomization Study
por: Gill, Dipender, et al.
Publicado: (2018)

Psoriasis and COVID-19: A bidirectional Mendelian randomization study
por: Chalitsios, Christos V., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_llf8pr07gr5mtqnvb5qrupii1d