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Stereological analysis of elastic fibers of the corpus cavernosum of rats during the aging process
PURPOSE: To evaluate changes in the quantity of elastic fibers in the corpora cavernosa of rats during the natural aging process, and to assess the degree of this change by determining volumetric density (Vv) at different ages via stereological analysis. METHODS: Forty-eight rats, raised under simil...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em
Cirurgia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799974/ https://www.ncbi.nlm.nih.gov/pubmed/31618403 http://dx.doi.org/10.1590/s0102-865020190080000003 |
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author | Hota, Thiago Lorenzini, Fernando Melchioretto, Eduardo Felippe Zeni, Marcelo Veronez, Djanira Aparecida da Luz de Fraga, Rogério |
author_facet | Hota, Thiago Lorenzini, Fernando Melchioretto, Eduardo Felippe Zeni, Marcelo Veronez, Djanira Aparecida da Luz de Fraga, Rogério |
author_sort | Hota, Thiago |
collection | PubMed |
description | PURPOSE: To evaluate changes in the quantity of elastic fibers in the corpora cavernosa of rats during the natural aging process, and to assess the degree of this change by determining volumetric density (Vv) at different ages via stereological analysis. METHODS: Forty-eight rats, raised under similar conditions, were subjected to the natural aging process and divided into four groups (G1 to G4), according to age at the time of penectomy (6, 9, 12, and 24 months, respectively). Histological sections of the middle segment of the penis were stained with Weigert’s resorcin-fuchsin, and the volumetric density (Vv) of elastic fibers of the corpora cavernosa were determined via stereological analysis. RESULTS: There were no statistically significant differences in Vv among groups G1, G2, and G3. These three groups were therefore considered as a single group. The mean Vv of this group showed a statistically significant reduction compared to that of G4 (0.16 vs. 0.11, p<0.05). CONCLUSION: Natural aging in rats was responsible for a reduction in volumetric density of elastic fibers of the corpora cavernosa (approximately 30% decrease in Vv) during senescence. |
format | Online Article Text |
id | pubmed-6799974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em
Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-67999742019-10-29 Stereological analysis of elastic fibers of the corpus cavernosum of rats during the aging process Hota, Thiago Lorenzini, Fernando Melchioretto, Eduardo Felippe Zeni, Marcelo Veronez, Djanira Aparecida da Luz de Fraga, Rogério Acta Cir Bras ORIGINAL ARTICLE PURPOSE: To evaluate changes in the quantity of elastic fibers in the corpora cavernosa of rats during the natural aging process, and to assess the degree of this change by determining volumetric density (Vv) at different ages via stereological analysis. METHODS: Forty-eight rats, raised under similar conditions, were subjected to the natural aging process and divided into four groups (G1 to G4), according to age at the time of penectomy (6, 9, 12, and 24 months, respectively). Histological sections of the middle segment of the penis were stained with Weigert’s resorcin-fuchsin, and the volumetric density (Vv) of elastic fibers of the corpora cavernosa were determined via stereological analysis. RESULTS: There were no statistically significant differences in Vv among groups G1, G2, and G3. These three groups were therefore considered as a single group. The mean Vv of this group showed a statistically significant reduction compared to that of G4 (0.16 vs. 0.11, p<0.05). CONCLUSION: Natural aging in rats was responsible for a reduction in volumetric density of elastic fibers of the corpora cavernosa (approximately 30% decrease in Vv) during senescence. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2019-10-14 /pmc/articles/PMC6799974/ /pubmed/31618403 http://dx.doi.org/10.1590/s0102-865020190080000003 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | ORIGINAL ARTICLE Hota, Thiago Lorenzini, Fernando Melchioretto, Eduardo Felippe Zeni, Marcelo Veronez, Djanira Aparecida da Luz de Fraga, Rogério Stereological analysis of elastic fibers of the corpus cavernosum of rats during the aging process |
title | Stereological analysis of elastic fibers of the corpus cavernosum of
rats during the aging process
|
title_full | Stereological analysis of elastic fibers of the corpus cavernosum of
rats during the aging process
|
title_fullStr | Stereological analysis of elastic fibers of the corpus cavernosum of
rats during the aging process
|
title_full_unstemmed | Stereological analysis of elastic fibers of the corpus cavernosum of
rats during the aging process
|
title_short | Stereological analysis of elastic fibers of the corpus cavernosum of
rats during the aging process
|
title_sort | stereological analysis of elastic fibers of the corpus cavernosum of
rats during the aging process |
topic | ORIGINAL ARTICLE |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6799974/ https://www.ncbi.nlm.nih.gov/pubmed/31618403 http://dx.doi.org/10.1590/s0102-865020190080000003 |
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