Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation

Elevated homocysteine (Hcy) levels have been shown to activate nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome leading to podocyte dysfunction and glomerular injury. However, it remains unclear how this inflammasome activation in podocytes is a...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Qinghua, Conley, Sabena M., Li, Guangbi, Yuan, Xinxu, Li, Pin-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800118/
https://www.ncbi.nlm.nih.gov/pubmed/31266025
http://dx.doi.org/10.1159/000500457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800118/
https://www.ncbi.nlm.nih.gov/pubmed/31266025
http://dx.doi.org/10.1159/000500457

Ejemplares similares