The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-β/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer

The ubiquitin-proteasome pathway plays an important role in the regulation of cellular proteins. As an alternative to the proteasome itself, recent research has focused on methods to modulate the regulation of deubiquitinating enzymes (DUBs) upstream of the proteasome, identifying DUBs as novel ther...

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Detalles Bibliográficos
Autores principales: Fukui, Shiho, Nagasaka, Kazunori, Miyagawa, Yuko, Kikuchi-Koike, Ryoko, Kawata, Yoshiko, Kanda, Ranka, Ichinose, Takayuki, Sugihara, Takeru, Hiraike, Haruko, Wada-Hiraike, Osamu, Sasajima, Yuko, Ayabe, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800272/
https://www.ncbi.nlm.nih.gov/pubmed/31666925
http://dx.doi.org/10.18632/oncotarget.27219

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