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Puma genomes from North and South America provide insights into the genomic consequences of inbreeding
Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced indi...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800433/ https://www.ncbi.nlm.nih.gov/pubmed/31628318 http://dx.doi.org/10.1038/s41467-019-12741-1 |
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author | Saremi, Nedda F. Supple, Megan A. Byrne, Ashley Cahill, James A. Coutinho, Luiz Lehmann Dalén, Love Figueiró, Henrique V. Johnson, Warren E. Milne, Heather J. O’Brien, Stephen J. O’Connell, Brendan Onorato, David P. Riley, Seth P. D. Sikich, Jeff A. Stahler, Daniel R. Villela, Priscilla Marqui Schmidt Vollmers, Christopher Wayne, Robert K. Eizirik, Eduardo Corbett-Detig, Russell B. Green, Richard E. Wilmers, Christopher C. Shapiro, Beth |
author_facet | Saremi, Nedda F. Supple, Megan A. Byrne, Ashley Cahill, James A. Coutinho, Luiz Lehmann Dalén, Love Figueiró, Henrique V. Johnson, Warren E. Milne, Heather J. O’Brien, Stephen J. O’Connell, Brendan Onorato, David P. Riley, Seth P. D. Sikich, Jeff A. Stahler, Daniel R. Villela, Priscilla Marqui Schmidt Vollmers, Christopher Wayne, Robert K. Eizirik, Eduardo Corbett-Detig, Russell B. Green, Richard E. Wilmers, Christopher C. Shapiro, Beth |
author_sort | Saremi, Nedda F. |
collection | PubMed |
description | Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300–100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations. |
format | Online Article Text |
id | pubmed-6800433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68004332019-10-21 Puma genomes from North and South America provide insights into the genomic consequences of inbreeding Saremi, Nedda F. Supple, Megan A. Byrne, Ashley Cahill, James A. Coutinho, Luiz Lehmann Dalén, Love Figueiró, Henrique V. Johnson, Warren E. Milne, Heather J. O’Brien, Stephen J. O’Connell, Brendan Onorato, David P. Riley, Seth P. D. Sikich, Jeff A. Stahler, Daniel R. Villela, Priscilla Marqui Schmidt Vollmers, Christopher Wayne, Robert K. Eizirik, Eduardo Corbett-Detig, Russell B. Green, Richard E. Wilmers, Christopher C. Shapiro, Beth Nat Commun Article Pumas are the most widely distributed felid in the Western Hemisphere. Increasingly, however, human persecution and habitat loss are isolating puma populations. To explore the genomic consequences of this isolation, we assemble a draft puma genome and a geographically broad panel of resequenced individuals. We estimate that the lineage leading to present-day North American pumas diverged from South American lineages 300–100 thousand years ago. We find signatures of close inbreeding in geographically isolated North American populations, but also that tracts of homozygosity are rarely shared among these populations, suggesting that assisted gene flow would restore local genetic diversity. The genome of a Florida panther descended from translocated Central American individuals has long tracts of homozygosity despite recent outbreeding. This suggests that while translocations may introduce diversity, sustaining diversity in small and isolated populations will require either repeated translocations or restoration of landscape connectivity. Our approach provides a framework for genome-wide analyses that can be applied to the management of similarly small and isolated populations. Nature Publishing Group UK 2019-10-18 /pmc/articles/PMC6800433/ /pubmed/31628318 http://dx.doi.org/10.1038/s41467-019-12741-1 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Saremi, Nedda F. Supple, Megan A. Byrne, Ashley Cahill, James A. Coutinho, Luiz Lehmann Dalén, Love Figueiró, Henrique V. Johnson, Warren E. Milne, Heather J. O’Brien, Stephen J. O’Connell, Brendan Onorato, David P. Riley, Seth P. D. Sikich, Jeff A. Stahler, Daniel R. Villela, Priscilla Marqui Schmidt Vollmers, Christopher Wayne, Robert K. Eizirik, Eduardo Corbett-Detig, Russell B. Green, Richard E. Wilmers, Christopher C. Shapiro, Beth Puma genomes from North and South America provide insights into the genomic consequences of inbreeding |
title | Puma genomes from North and South America provide insights into the genomic consequences of inbreeding |
title_full | Puma genomes from North and South America provide insights into the genomic consequences of inbreeding |
title_fullStr | Puma genomes from North and South America provide insights into the genomic consequences of inbreeding |
title_full_unstemmed | Puma genomes from North and South America provide insights into the genomic consequences of inbreeding |
title_short | Puma genomes from North and South America provide insights into the genomic consequences of inbreeding |
title_sort | puma genomes from north and south america provide insights into the genomic consequences of inbreeding |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800433/ https://www.ncbi.nlm.nih.gov/pubmed/31628318 http://dx.doi.org/10.1038/s41467-019-12741-1 |
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