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Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila
Animals perform or terminate particular behaviors by integrating external cues and internal states through neural circuits. Identifying neural substrates and their molecular modulators promoting or inhibiting animal behaviors are key steps to understand how neural circuits control behaviors. Here, w...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800437/ https://www.ncbi.nlm.nih.gov/pubmed/31628317 http://dx.doi.org/10.1038/s41467-019-12758-6 |
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author | Wu, Shunfan Guo, Chao Zhao, Huan Sun, Mengshi Chen, Jie Han, Caihong Peng, Qionglin Qiao, Huanhuan Peng, Ping Liu, Yan Luo, Shengzhan D. Pan, Yufeng |
author_facet | Wu, Shunfan Guo, Chao Zhao, Huan Sun, Mengshi Chen, Jie Han, Caihong Peng, Qionglin Qiao, Huanhuan Peng, Ping Liu, Yan Luo, Shengzhan D. Pan, Yufeng |
author_sort | Wu, Shunfan |
collection | PubMed |
description | Animals perform or terminate particular behaviors by integrating external cues and internal states through neural circuits. Identifying neural substrates and their molecular modulators promoting or inhibiting animal behaviors are key steps to understand how neural circuits control behaviors. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) that functions at single-neuron resolution to suppress male sexual behavior in Drosophila. We found that Dsk neurons physiologically interact with male-specific P1 neurons, part of a command center for male sexual behaviors, and function oppositely to regulate multiple arousal-related behaviors including sex, sleep and spontaneous walking. We further found that the DSK-2 peptide functions through its receptor CCKLR-17D3 to suppress sexual behaviors in flies. Such a neuropeptide circuit largely overlaps with the fruitless-expressing neural circuit that governs most aspects of male sexual behaviors. Thus DSK/CCKLR signaling in the sex circuitry functions antagonistically with P1 neurons to balance arousal levels and modulate sexual behaviors. |
format | Online Article Text |
id | pubmed-6800437 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68004372019-10-21 Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila Wu, Shunfan Guo, Chao Zhao, Huan Sun, Mengshi Chen, Jie Han, Caihong Peng, Qionglin Qiao, Huanhuan Peng, Ping Liu, Yan Luo, Shengzhan D. Pan, Yufeng Nat Commun Article Animals perform or terminate particular behaviors by integrating external cues and internal states through neural circuits. Identifying neural substrates and their molecular modulators promoting or inhibiting animal behaviors are key steps to understand how neural circuits control behaviors. Here, we identify the Cholecystokinin-like peptide Drosulfakinin (DSK) that functions at single-neuron resolution to suppress male sexual behavior in Drosophila. We found that Dsk neurons physiologically interact with male-specific P1 neurons, part of a command center for male sexual behaviors, and function oppositely to regulate multiple arousal-related behaviors including sex, sleep and spontaneous walking. We further found that the DSK-2 peptide functions through its receptor CCKLR-17D3 to suppress sexual behaviors in flies. Such a neuropeptide circuit largely overlaps with the fruitless-expressing neural circuit that governs most aspects of male sexual behaviors. Thus DSK/CCKLR signaling in the sex circuitry functions antagonistically with P1 neurons to balance arousal levels and modulate sexual behaviors. Nature Publishing Group UK 2019-10-18 /pmc/articles/PMC6800437/ /pubmed/31628317 http://dx.doi.org/10.1038/s41467-019-12758-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wu, Shunfan Guo, Chao Zhao, Huan Sun, Mengshi Chen, Jie Han, Caihong Peng, Qionglin Qiao, Huanhuan Peng, Ping Liu, Yan Luo, Shengzhan D. Pan, Yufeng Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila |
title | Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila |
title_full | Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila |
title_fullStr | Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila |
title_full_unstemmed | Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila |
title_short | Drosulfakinin signaling in fruitless circuitry antagonizes P1 neurons to regulate sexual arousal in Drosophila |
title_sort | drosulfakinin signaling in fruitless circuitry antagonizes p1 neurons to regulate sexual arousal in drosophila |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800437/ https://www.ncbi.nlm.nih.gov/pubmed/31628317 http://dx.doi.org/10.1038/s41467-019-12758-6 |
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