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Sequence-specific m(6)A demethylation in RNA by FTO fused to RCas9
N(6)-methyladenosine (m(6)A) is the most common internal modification in eukaryotic mRNA and associated with numerous cellular processes in health and disease. Up- and down-regulation of its “writer” or “eraser” proteins alter the global m(6)A level; however, modifying distinct m(6)A sites has remai...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800472/ https://www.ncbi.nlm.nih.gov/pubmed/31263003 http://dx.doi.org/10.1261/rna.070706.119 |