Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China

PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we chara...

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Autores principales: Liu, Jiankui, Wei, Chunhua, Lin, Zhifeng, Xia, Wei, Ma, Ying, Dai, Ailing, Yang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2019
Materias:
Bioinformatics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800524/
https://www.ncbi.nlm.nih.gov/pubmed/31637126
http://dx.doi.org/10.7717/peerj.7859
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author Liu, Jiankui
Wei, Chunhua
Lin, Zhifeng
Xia, Wei
Ma, Ying
Dai, Ailing
Yang, Xiaoyan
author_facet Liu, Jiankui
Wei, Chunhua
Lin, Zhifeng
Xia, Wei
Ma, Ying
Dai, Ailing
Yang, Xiaoyan
author_sort Liu, Jiankui
collection PubMed
description PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we characterized the genetic characteristics of FJ0908. Phylogenetic analysis indicated that FJ0908 was related to 1-7-4-like strains circulating in the United States since 2014. Furthermore, the ORF5 sequence restriction fragment length polymorphism (RFLP) pattern of FJ0908 was 1-7-4. Additionally, FJ0908 had a 100 aa deletion (aa329–428) within nsp2, as compared to VR-2332, and the deletion pattern was consistent with most of 1-7-4 PRRSVs. Collectively, the data of this study contribute to the understanding of 1-7-4-like PRRSV molecular epidemiology in China.
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spelling pubmed-68005242019-10-21 Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China Liu, Jiankui Wei, Chunhua Lin, Zhifeng Xia, Wei Ma, Ying Dai, Ailing Yang, Xiaoyan PeerJ Bioinformatics PRRS virus (PRRSV) has undergone rapid evolution and resulted in immense economic losses worldwide. In the present study, a PRRSV strain named FJ0908 causing high abortion rate (25%) and mortality (40%) was detected in a swine herd in China. To determine if a new PRRSV genotype had emerged, we characterized the genetic characteristics of FJ0908. Phylogenetic analysis indicated that FJ0908 was related to 1-7-4-like strains circulating in the United States since 2014. Furthermore, the ORF5 sequence restriction fragment length polymorphism (RFLP) pattern of FJ0908 was 1-7-4. Additionally, FJ0908 had a 100 aa deletion (aa329–428) within nsp2, as compared to VR-2332, and the deletion pattern was consistent with most of 1-7-4 PRRSVs. Collectively, the data of this study contribute to the understanding of 1-7-4-like PRRSV molecular epidemiology in China. PeerJ Inc. 2019-10-16 /pmc/articles/PMC6800524/ /pubmed/31637126 http://dx.doi.org/10.7717/peerj.7859 Text en ©2019 Liu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Bioinformatics
Liu, Jiankui
Wei, Chunhua
Lin, Zhifeng
Xia, Wei
Ma, Ying
Dai, Ailing
Yang, Xiaoyan
Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China
title Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China
title_full Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China
title_fullStr Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China
title_full_unstemmed Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China
title_short Full genome sequence analysis of a 1-7-4-like PRRSV strain in Fujian Province, China
title_sort full genome sequence analysis of a 1-7-4-like prrsv strain in fujian province, china
topic Bioinformatics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800524/
https://www.ncbi.nlm.nih.gov/pubmed/31637126
http://dx.doi.org/10.7717/peerj.7859
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