Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray

Proprotein convertase subtilisin-kexin 9 (PCSK9) appears to be involved in multiple processes. A ProtoArray Human Protein Microarray was used to identify proteins interacting with biotinylated PCSK9. Fifteen novel proteins interacting with PCSK9 were identified using this technique. Only two of thes...

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Autores principales: Wooten, Catherine J., Krishnaji, Sreevidhya T., Melendez, Quantil M., Lopez, Dayami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800654/
https://www.ncbi.nlm.nih.gov/pubmed/31633088
http://dx.doi.org/10.31531/2581-4745.1000120
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author Wooten, Catherine J.
Krishnaji, Sreevidhya T.
Melendez, Quantil M.
Lopez, Dayami
author_facet Wooten, Catherine J.
Krishnaji, Sreevidhya T.
Melendez, Quantil M.
Lopez, Dayami
author_sort Wooten, Catherine J.
collection PubMed
description Proprotein convertase subtilisin-kexin 9 (PCSK9) appears to be involved in multiple processes. A ProtoArray Human Protein Microarray was used to identify proteins interacting with biotinylated PCSK9. Fifteen novel proteins interacting with PCSK9 were identified using this technique. Only two of these proteins, sterol carrier protein 2 and hepatoma-derived growth factor, related protein 3, have known functions. The identification of proteins that could affect the expression/function of PCSK9 is of great interest due to potential implications in personalized medicine for hypercholesterolemic patients.
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spelling pubmed-68006542019-10-19 Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray Wooten, Catherine J. Krishnaji, Sreevidhya T. Melendez, Quantil M. Lopez, Dayami Int J Biomed Investig Article Proprotein convertase subtilisin-kexin 9 (PCSK9) appears to be involved in multiple processes. A ProtoArray Human Protein Microarray was used to identify proteins interacting with biotinylated PCSK9. Fifteen novel proteins interacting with PCSK9 were identified using this technique. Only two of these proteins, sterol carrier protein 2 and hepatoma-derived growth factor, related protein 3, have known functions. The identification of proteins that could affect the expression/function of PCSK9 is of great interest due to potential implications in personalized medicine for hypercholesterolemic patients. 2019-09-18 2019 /pmc/articles/PMC6800654/ /pubmed/31633088 http://dx.doi.org/10.31531/2581-4745.1000120 Text en http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 International License [http://creativecommons.org/licenses/by/4.0/], which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author[s] and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Wooten, Catherine J.
Krishnaji, Sreevidhya T.
Melendez, Quantil M.
Lopez, Dayami
Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray
title Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray
title_full Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray
title_fullStr Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray
title_full_unstemmed Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray
title_short Identification of Proteins Interacting with PCSK9 Using a Protoarray Human Protein Microarray
title_sort identification of proteins interacting with pcsk9 using a protoarray human protein microarray
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800654/
https://www.ncbi.nlm.nih.gov/pubmed/31633088
http://dx.doi.org/10.31531/2581-4745.1000120
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