Pueraria lobata and Daidzein Reduce Cytotoxicity by Enhancing Ubiquitin-Proteasome System Function in SCA3-iPSC-Derived Neurons

Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion within the ATXN3/MJD1 gene. The expanded CAG repeats encode a polyglutamine (polyQ) tract at the C-terminus of the ATXN3 protein. ATXN3 containing expanded polyQ forms aggregates...

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Detalles Bibliográficos
Autores principales: Chen, I-Cheng, Chang, Kuo-Hsuan, Chen, Yi-Jing, Chen, Yi-Chun, Lee-Chen, Guey-Jen, Chen, Chiung-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800904/
https://www.ncbi.nlm.nih.gov/pubmed/31687087
http://dx.doi.org/10.1155/2019/8130481

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