(11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia

There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as (11)C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, w...

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Detalles Bibliográficos
Autores principales: Nicastro, Nicolas, Surendranathan, Ajenthan, Mak, Elijah, Rowe, James B., O’Brien, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801158/
https://www.ncbi.nlm.nih.gov/pubmed/31507085
http://dx.doi.org/10.1002/acn3.50877
Descripción
Sumario:There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as (11)C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, we studied five subjects with Parkinson’s disease dementia (PDD). Our findings suggest that while DTI metrics mirror cognitive severity, higher (11)C‐PK11195 binding seems to be associated with a relative preservation of both white matter tracts and cognition. Longitudinal studies are warranted to tackle the complex relationship between microglial activation and structural abnormalities in neurodegenerative conditions.

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