(11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia

There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as (11)C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, w...

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Autores principales: Nicastro, Nicolas, Surendranathan, Ajenthan, Mak, Elijah, Rowe, James B., O’Brien, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801158/
https://www.ncbi.nlm.nih.gov/pubmed/31507085
http://dx.doi.org/10.1002/acn3.50877
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author Nicastro, Nicolas
Surendranathan, Ajenthan
Mak, Elijah
Rowe, James B.
O’Brien, John T.
author_facet Nicastro, Nicolas
Surendranathan, Ajenthan
Mak, Elijah
Rowe, James B.
O’Brien, John T.
author_sort Nicastro, Nicolas
collection PubMed
description There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as (11)C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, we studied five subjects with Parkinson’s disease dementia (PDD). Our findings suggest that while DTI metrics mirror cognitive severity, higher (11)C‐PK11195 binding seems to be associated with a relative preservation of both white matter tracts and cognition. Longitudinal studies are warranted to tackle the complex relationship between microglial activation and structural abnormalities in neurodegenerative conditions.
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spelling pubmed-68011582019-10-22 (11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia Nicastro, Nicolas Surendranathan, Ajenthan Mak, Elijah Rowe, James B. O’Brien, John T. Ann Clin Transl Neurol Case Study There is evidence of increased microglial activation in Parkinson’s disease (PD) as shown by in vivo PET ligand such as (11)C‐PK11195. In addition, diffusion tensor imaging (DTI) imaging reveals widespread changes in PD, especially when the associated dementia develops. In the present case series, we studied five subjects with Parkinson’s disease dementia (PDD). Our findings suggest that while DTI metrics mirror cognitive severity, higher (11)C‐PK11195 binding seems to be associated with a relative preservation of both white matter tracts and cognition. Longitudinal studies are warranted to tackle the complex relationship between microglial activation and structural abnormalities in neurodegenerative conditions. John Wiley and Sons Inc. 2019-09-10 /pmc/articles/PMC6801158/ /pubmed/31507085 http://dx.doi.org/10.1002/acn3.50877 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Study
Nicastro, Nicolas
Surendranathan, Ajenthan
Mak, Elijah
Rowe, James B.
O’Brien, John T.
(11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
title (11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
title_full (11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
title_fullStr (11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
title_full_unstemmed (11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
title_short (11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
title_sort (11)c‐pk11195 pet imaging and white matter changes in parkinson’s disease dementia
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801158/
https://www.ncbi.nlm.nih.gov/pubmed/31507085
http://dx.doi.org/10.1002/acn3.50877
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AT rowejamesb 11cpk11195petimagingandwhitematterchangesinparkinsonsdiseasedementia
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