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Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures

BACKGROUND: The esophagus is the most common part of gastrointestinal (GI) tract at the risk of stricture. Benign disorders are the leading causes of narrowing. Caustic ingestion is the most common cause of esophageal stricture in children, especially in developing countries. Clinical responses to t...

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Autores principales: Rashed, Yasser K., El-Guindi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Pediatric Society 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801201/
https://www.ncbi.nlm.nih.gov/pubmed/31319649
http://dx.doi.org/10.3345/kjp.2018.07157
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author Rashed, Yasser K.
El-Guindi, Mohamed
author_facet Rashed, Yasser K.
El-Guindi, Mohamed
author_sort Rashed, Yasser K.
collection PubMed
description BACKGROUND: The esophagus is the most common part of gastrointestinal (GI) tract at the risk of stricture. Benign disorders are the leading causes of narrowing. Caustic ingestion is the most common cause of esophageal stricture in children, especially in developing countries. Clinical responses to the topical application of Mitomycin C in various medical procedures have been reported. PURPOSE: The study aimed to evaluate the methodology, efficacy, and side effects of Mitomycin C in the treatment of esophageal strictures. METHODS: This study included 30 children with resistant esophageal strictures. Upper GI endoscopy was performed up to the area of stricture, esophageal dilatation was done, endoscopy was repeated, and Mitomycin C was applied topically under direct endoscopic vision. The effect of the procedure was followed over a period of 3–5 years. RESULTS: The response to Mitomycin C was excellent (clinically and endoscopically) in 28 patients (93.3%) and good (endoscopically only) in 2 patients (6.7%). No side effects of topical Mitomycin C in children with esophageal strictures were reported in this study. CONCLUSION: Esophageal dilatation followed by local Mitomycin C application may be a useful strategy for treating resistant esophageal strictures.
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spelling pubmed-68012012019-10-29 Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures Rashed, Yasser K. El-Guindi, Mohamed Korean J Pediatr Original Article BACKGROUND: The esophagus is the most common part of gastrointestinal (GI) tract at the risk of stricture. Benign disorders are the leading causes of narrowing. Caustic ingestion is the most common cause of esophageal stricture in children, especially in developing countries. Clinical responses to the topical application of Mitomycin C in various medical procedures have been reported. PURPOSE: The study aimed to evaluate the methodology, efficacy, and side effects of Mitomycin C in the treatment of esophageal strictures. METHODS: This study included 30 children with resistant esophageal strictures. Upper GI endoscopy was performed up to the area of stricture, esophageal dilatation was done, endoscopy was repeated, and Mitomycin C was applied topically under direct endoscopic vision. The effect of the procedure was followed over a period of 3–5 years. RESULTS: The response to Mitomycin C was excellent (clinically and endoscopically) in 28 patients (93.3%) and good (endoscopically only) in 2 patients (6.7%). No side effects of topical Mitomycin C in children with esophageal strictures were reported in this study. CONCLUSION: Esophageal dilatation followed by local Mitomycin C application may be a useful strategy for treating resistant esophageal strictures. Korean Pediatric Society 2019-10 2019-06-24 /pmc/articles/PMC6801201/ /pubmed/31319649 http://dx.doi.org/10.3345/kjp.2018.07157 Text en Copyright © 2019 by The Korean Pediatric Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rashed, Yasser K.
El-Guindi, Mohamed
Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
title Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
title_full Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
title_fullStr Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
title_full_unstemmed Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
title_short Endoscopic postdilatation application of Mitomycin C in children with resistant esophageal strictures
title_sort endoscopic postdilatation application of mitomycin c in children with resistant esophageal strictures
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801201/
https://www.ncbi.nlm.nih.gov/pubmed/31319649
http://dx.doi.org/10.3345/kjp.2018.07157
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