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Brain lesion distribution criteria distinguish demyelinating diseases in China

OBJECTIVE: To verify the utility of brain lesion distribution criteria in distinguishing multiple sclerosis (MS) from aquaporin‐4 (AQP4)‐immunoglobulin G (IgG)‐positive/‐negative neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein IgG‐associated encephalomyelitis (...

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Autores principales: Cai, Meng‐Ting, Zhang, Yin‐Xi, Zheng, Yang, Yang, Fan, Fang, Wei, Shen, Chun‐Hong, Ding, Mei‐Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801206/
https://www.ncbi.nlm.nih.gov/pubmed/31566925
http://dx.doi.org/10.1002/acn3.50913
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author Cai, Meng‐Ting
Zhang, Yin‐Xi
Zheng, Yang
Yang, Fan
Fang, Wei
Shen, Chun‐Hong
Ding, Mei‐Ping
author_facet Cai, Meng‐Ting
Zhang, Yin‐Xi
Zheng, Yang
Yang, Fan
Fang, Wei
Shen, Chun‐Hong
Ding, Mei‐Ping
author_sort Cai, Meng‐Ting
collection PubMed
description OBJECTIVE: To verify the utility of brain lesion distribution criteria in distinguishing multiple sclerosis (MS) from aquaporin‐4 (AQP4)‐immunoglobulin G (IgG)‐positive/‐negative neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein IgG‐associated encephalomyelitis (MOG‐EM) in the Chinese population. METHODS: A total of 253 patients with MS (80), NMOSD (129 AQP4‐IgG positive, 34 AQP4‐IgG negative), and MOG‐EM (10) were enrolled. Anonymized magnetic resonance imaging results were scored on the previous reported criteria of “at least one lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or the presence of a subcortical U‐fiber lesion; or a Dawson’s finger‐type lesion.” Chi‐squared test (or Fisher’s exact test) was used to analyze the data. RESULTS: The distribution criteria were able to distinguish MS with a same sensitivity of 93.8% from all type of NMOSD and MOG‐EM, with a specificity of 89.7% from the whole NMOSD cohort, 89.1% from AQP4‐IgG‐positive NMOSD 91.2% from AQP4‐IgG‐negative NMOSD, and 70.0% from MOG‐EM. Dawson's finger‐type lesion was the most sensitive and specific feature, whereas the U‐fiber lesion was the least. CONCLUSION: The brain lesion distribution criteria were helpful in distinguishing MS from NMOSD and MOG‐EM in the Chinese population. Dawson's finger‐type lesion was highly suggestive of MS.
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spelling pubmed-68012062019-10-22 Brain lesion distribution criteria distinguish demyelinating diseases in China Cai, Meng‐Ting Zhang, Yin‐Xi Zheng, Yang Yang, Fan Fang, Wei Shen, Chun‐Hong Ding, Mei‐Ping Ann Clin Transl Neurol Research Articles OBJECTIVE: To verify the utility of brain lesion distribution criteria in distinguishing multiple sclerosis (MS) from aquaporin‐4 (AQP4)‐immunoglobulin G (IgG)‐positive/‐negative neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein IgG‐associated encephalomyelitis (MOG‐EM) in the Chinese population. METHODS: A total of 253 patients with MS (80), NMOSD (129 AQP4‐IgG positive, 34 AQP4‐IgG negative), and MOG‐EM (10) were enrolled. Anonymized magnetic resonance imaging results were scored on the previous reported criteria of “at least one lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or the presence of a subcortical U‐fiber lesion; or a Dawson’s finger‐type lesion.” Chi‐squared test (or Fisher’s exact test) was used to analyze the data. RESULTS: The distribution criteria were able to distinguish MS with a same sensitivity of 93.8% from all type of NMOSD and MOG‐EM, with a specificity of 89.7% from the whole NMOSD cohort, 89.1% from AQP4‐IgG‐positive NMOSD 91.2% from AQP4‐IgG‐negative NMOSD, and 70.0% from MOG‐EM. Dawson's finger‐type lesion was the most sensitive and specific feature, whereas the U‐fiber lesion was the least. CONCLUSION: The brain lesion distribution criteria were helpful in distinguishing MS from NMOSD and MOG‐EM in the Chinese population. Dawson's finger‐type lesion was highly suggestive of MS. John Wiley and Sons Inc. 2019-09-30 /pmc/articles/PMC6801206/ /pubmed/31566925 http://dx.doi.org/10.1002/acn3.50913 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Cai, Meng‐Ting
Zhang, Yin‐Xi
Zheng, Yang
Yang, Fan
Fang, Wei
Shen, Chun‐Hong
Ding, Mei‐Ping
Brain lesion distribution criteria distinguish demyelinating diseases in China
title Brain lesion distribution criteria distinguish demyelinating diseases in China
title_full Brain lesion distribution criteria distinguish demyelinating diseases in China
title_fullStr Brain lesion distribution criteria distinguish demyelinating diseases in China
title_full_unstemmed Brain lesion distribution criteria distinguish demyelinating diseases in China
title_short Brain lesion distribution criteria distinguish demyelinating diseases in China
title_sort brain lesion distribution criteria distinguish demyelinating diseases in china
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801206/
https://www.ncbi.nlm.nih.gov/pubmed/31566925
http://dx.doi.org/10.1002/acn3.50913
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