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First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus

Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β...

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Autores principales: Visconti, Federica, Quaresima, Paola, Chiefari, Eusebio, Caroleo, Patrizia, Arcidiacono, Biagio, Puccio, Luigi, Mirabelli, Maria, Foti, Daniela P., Di Carlo, Costantino, Vero, Raffaella, Brunetti, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801433/
https://www.ncbi.nlm.nih.gov/pubmed/31569431
http://dx.doi.org/10.3390/ijerph16193654
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author Visconti, Federica
Quaresima, Paola
Chiefari, Eusebio
Caroleo, Patrizia
Arcidiacono, Biagio
Puccio, Luigi
Mirabelli, Maria
Foti, Daniela P.
Di Carlo, Costantino
Vero, Raffaella
Brunetti, Antonio
author_facet Visconti, Federica
Quaresima, Paola
Chiefari, Eusebio
Caroleo, Patrizia
Arcidiacono, Biagio
Puccio, Luigi
Mirabelli, Maria
Foti, Daniela P.
Di Carlo, Costantino
Vero, Raffaella
Brunetti, Antonio
author_sort Visconti, Federica
collection PubMed
description Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods—2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11–13 weeks (plus 6 days) of gestation, and screening for GDM at 16–18 and/or 24–28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results—1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis (ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT <1:10000 had a major GDM risk (p = 0.016), similar to women with a PAPP-A <1 multiple of the expected normal median (MoM, p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM (p = 0.014). Conclusions—Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM.
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spelling pubmed-68014332019-10-31 First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus Visconti, Federica Quaresima, Paola Chiefari, Eusebio Caroleo, Patrizia Arcidiacono, Biagio Puccio, Luigi Mirabelli, Maria Foti, Daniela P. Di Carlo, Costantino Vero, Raffaella Brunetti, Antonio Int J Environ Res Public Health Article Background—The first trimester combined test (FTCT) is an effective screening tool to estimate the risk of fetal aneuploidy. It is obtained by the combination of maternal age, ultrasound fetal nuchal translucency (NT) measurement, and the maternal serum markers free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A). However, conflicting data have been reported about the association of FTCT, β-hCG, or PAPP-A with the subsequent diagnosis of gestational diabetes mellitus (GDM). Research design and methods—2410 consecutive singleton pregnant women were retrospectively enrolled in Calabria, Southern Italy. All participants underwent examinations for FTCT at 11–13 weeks (plus 6 days) of gestation, and screening for GDM at 16–18 and/or 24–28 weeks of gestation, in accordance with current Italian guidelines and the International Association Diabetes Pregnancy Study Groups (IADPSG) glycemic cut-offs. Data were examined by univariate and logistic regression analyses. Results—1814 (75.3%) pregnant women were normal glucose tolerant, while 596 (24.7%) were diagnosed with GDM. Spearman univariate analysis demonstrated a correlation between FTCT values and subsequent GDM diagnosis (ρ = 0.048, p = 0.018). The logistic regression analysis showed that women with a FTCT <1:10000 had a major GDM risk (p = 0.016), similar to women with a PAPP-A <1 multiple of the expected normal median (MoM, p = 0.014). Conversely, women with β-hCG ≥2.0 MoM had a reduced risk of GDM (p = 0.014). Conclusions—Our findings indicate that GDM susceptibility increases with fetal aneuploidy risk, and that FTCT and its related maternal serum parameters can be used as early predictors of GDM. MDPI 2019-09-28 2019-10 /pmc/articles/PMC6801433/ /pubmed/31569431 http://dx.doi.org/10.3390/ijerph16193654 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Visconti, Federica
Quaresima, Paola
Chiefari, Eusebio
Caroleo, Patrizia
Arcidiacono, Biagio
Puccio, Luigi
Mirabelli, Maria
Foti, Daniela P.
Di Carlo, Costantino
Vero, Raffaella
Brunetti, Antonio
First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus
title First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus
title_full First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus
title_fullStr First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus
title_full_unstemmed First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus
title_short First Trimester Combined Test (FTCT) as a Predictor of Gestational Diabetes Mellitus
title_sort first trimester combined test (ftct) as a predictor of gestational diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801433/
https://www.ncbi.nlm.nih.gov/pubmed/31569431
http://dx.doi.org/10.3390/ijerph16193654
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