Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease

Calcium ions (Ca(2+)) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca(2+) currents through the inn...

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Autores principales: Tarasova, Nadezhda V., Vishnyakova, Polina A., Logashina, Yulia A., Elchaninov, Andrey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801532/
https://www.ncbi.nlm.nih.gov/pubmed/31569359
http://dx.doi.org/10.3390/ijms20194823
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author Tarasova, Nadezhda V.
Vishnyakova, Polina A.
Logashina, Yulia A.
Elchaninov, Andrey V.
author_facet Tarasova, Nadezhda V.
Vishnyakova, Polina A.
Logashina, Yulia A.
Elchaninov, Andrey V.
author_sort Tarasova, Nadezhda V.
collection PubMed
description Calcium ions (Ca(2+)) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca(2+) currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease.
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spelling pubmed-68015322019-10-31 Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease Tarasova, Nadezhda V. Vishnyakova, Polina A. Logashina, Yulia A. Elchaninov, Andrey V. Int J Mol Sci Review Calcium ions (Ca(2+)) influx to mitochondrial matrix is crucial for the life of a cell. Mitochondrial calcium uniporter (mtCU) is a protein complex which consists of the pore-forming subunit (MCU) and several regulatory subunits. MtCU is the main contributor to inward Ca(2+) currents through the inner mitochondrial membrane. Extensive investigations of mtCU involvement into normal and pathological molecular pathways started from the moment of discovery of its molecular components. A crucial role of mtCU in the control of these pathways is now recognized in both health and disease. In particular, impairments of mtCU function have been demonstrated for cardiovascular and skeletal muscle-associated pathologies. This review summarizes the current state of knowledge on mtCU structure, regulation, and function in different types of muscle tissues in health and disease. MDPI 2019-09-28 /pmc/articles/PMC6801532/ /pubmed/31569359 http://dx.doi.org/10.3390/ijms20194823 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tarasova, Nadezhda V.
Vishnyakova, Polina A.
Logashina, Yulia A.
Elchaninov, Andrey V.
Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
title Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
title_full Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
title_fullStr Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
title_full_unstemmed Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
title_short Mitochondrial Calcium Uniporter Structure and Function in Different Types of Muscle Tissues in Health and Disease
title_sort mitochondrial calcium uniporter structure and function in different types of muscle tissues in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801532/
https://www.ncbi.nlm.nih.gov/pubmed/31569359
http://dx.doi.org/10.3390/ijms20194823
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