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Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis

(1) Background: As the most common eye disease diagnosed in emergency departments, conjunctivitis has caused serious health and economic burdens worldwide. However, whether air pollution may be a risk factor for conjunctivitis is still inconsistent among current evidence. (2) Methods: We searched th...

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Autores principales: Chen, Renchao, Yang, Jun, Zhang, Chunlin, Li, Bixia, Bergmann, Stéphanie, Zeng, Fangfang, Wang, Hao, Wang, Boguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801537/
https://www.ncbi.nlm.nih.gov/pubmed/31569424
http://dx.doi.org/10.3390/ijerph16193652
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author Chen, Renchao
Yang, Jun
Zhang, Chunlin
Li, Bixia
Bergmann, Stéphanie
Zeng, Fangfang
Wang, Hao
Wang, Boguang
author_facet Chen, Renchao
Yang, Jun
Zhang, Chunlin
Li, Bixia
Bergmann, Stéphanie
Zeng, Fangfang
Wang, Hao
Wang, Boguang
author_sort Chen, Renchao
collection PubMed
description (1) Background: As the most common eye disease diagnosed in emergency departments, conjunctivitis has caused serious health and economic burdens worldwide. However, whether air pollution may be a risk factor for conjunctivitis is still inconsistent among current evidence. (2) Methods: We searched the literature on the relationship between air pollution and conjunctivitis in multiple English databases before 18 March 2019. Meta-analysis, meta-regression, and funnel plots were used to integrate the data, identify the sources of bias, and determine the publication bias, respectively. (3) Results: A total of 2450 papers were found, 12 of which were finally included. The pooled relative risk for each 10 μg/m(3) increase of air pollution on conjunctivitis was 1.0006 (95%CI: 0.9993–1.0019) for CO, 1.0287 (1.0120–1.0457) for NO(2), 1.0089 (1.0030–1.0149) for O(3), 1.0004 (0.9976–1.0032) for PM(2.5), 1.0033 (0.9982–1.0083) for PM(10), and 1.0045 (0.9908–1.0185) for SO(2). In the subgroup, PM(2.5) and O(3) had a greater impact on conjunctivitis risk in women than in men, and people <18 years old than those ≥18 years old. Relative humidity significantly modified the risk of O(3) on conjunctivitis (p = 0.023), explaining 45% of the between-study heterogeneity. (4) Conclusion: Globally, air pollution has considerable health risks for conjunctivitis. Females and the youth were more vulnerable to PM(2.5), NO(2), and O(3). Reductions of air pollution levels are still warranted to protect the vulnerable populations.
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spelling pubmed-68015372019-10-31 Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis Chen, Renchao Yang, Jun Zhang, Chunlin Li, Bixia Bergmann, Stéphanie Zeng, Fangfang Wang, Hao Wang, Boguang Int J Environ Res Public Health Review (1) Background: As the most common eye disease diagnosed in emergency departments, conjunctivitis has caused serious health and economic burdens worldwide. However, whether air pollution may be a risk factor for conjunctivitis is still inconsistent among current evidence. (2) Methods: We searched the literature on the relationship between air pollution and conjunctivitis in multiple English databases before 18 March 2019. Meta-analysis, meta-regression, and funnel plots were used to integrate the data, identify the sources of bias, and determine the publication bias, respectively. (3) Results: A total of 2450 papers were found, 12 of which were finally included. The pooled relative risk for each 10 μg/m(3) increase of air pollution on conjunctivitis was 1.0006 (95%CI: 0.9993–1.0019) for CO, 1.0287 (1.0120–1.0457) for NO(2), 1.0089 (1.0030–1.0149) for O(3), 1.0004 (0.9976–1.0032) for PM(2.5), 1.0033 (0.9982–1.0083) for PM(10), and 1.0045 (0.9908–1.0185) for SO(2). In the subgroup, PM(2.5) and O(3) had a greater impact on conjunctivitis risk in women than in men, and people <18 years old than those ≥18 years old. Relative humidity significantly modified the risk of O(3) on conjunctivitis (p = 0.023), explaining 45% of the between-study heterogeneity. (4) Conclusion: Globally, air pollution has considerable health risks for conjunctivitis. Females and the youth were more vulnerable to PM(2.5), NO(2), and O(3). Reductions of air pollution levels are still warranted to protect the vulnerable populations. MDPI 2019-09-28 2019-10 /pmc/articles/PMC6801537/ /pubmed/31569424 http://dx.doi.org/10.3390/ijerph16193652 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chen, Renchao
Yang, Jun
Zhang, Chunlin
Li, Bixia
Bergmann, Stéphanie
Zeng, Fangfang
Wang, Hao
Wang, Boguang
Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis
title Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis
title_full Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis
title_fullStr Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis
title_full_unstemmed Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis
title_short Global Associations of Air Pollution and Conjunctivitis Diseases: A Systematic Review and Meta-Analysis
title_sort global associations of air pollution and conjunctivitis diseases: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801537/
https://www.ncbi.nlm.nih.gov/pubmed/31569424
http://dx.doi.org/10.3390/ijerph16193652
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