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Transforming Growth Factor-β1 Selectively Recruits microRNAs to the RNA-Induced Silencing Complex and Degrades CFTR mRNA under Permissive Conditions in Human Bronchial Epithelial Cells

Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene lead to cystic fibrosis (CF). The most common mutation F508del inhibits folding and processing of CFTR protein. FDA-approved correctors rescue the biosynthetic processing of F508del-CFTR protein, while potentiators impr...

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Detalles Bibliográficos
Autores principales:	Mitash, Nilay, Mu, Fangping, Donovan, Joshua E., Myerburg, Michael M., Ranganathan, Sarangarajan, Greene, Catherine M., Swiatecka-Urban, Agnieszka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801718/ https://www.ncbi.nlm.nih.gov/pubmed/31590401 http://dx.doi.org/10.3390/ijms20194933

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