Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms

WWP2 is an E3 ubiquitin ligase that differentially regulates the contextual tumour suppressor/progressor TGFβ signalling pathway by alternate isoform expression. WWP2 isoforms select signal transducer Smad2/3 or inhibitor Smad7 substrates for degradation through different compositions of protein–pro...

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Detalles Bibliográficos
Autores principales: Wahl, Lloyd C., Watt, Jessica E., Yim, Hiu T. T., De Bourcier, Danielle, Tolchard, James, Soond, Surinder M., Blumenschein, Tharin M. A., Chantry, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801763/
https://www.ncbi.nlm.nih.gov/pubmed/31546607
http://dx.doi.org/10.3390/ijms20194682

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