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Computed Tomography Assessment of Brain Atrophy in Centenarians

The aim of our study was to compare the degree of brain atrophy in centenarians and in seniors 70–99 years old. The study group consisted of 23 patients aged 100–106 years. The control group consisted of 90 patients, 30 in each age subgroup 90–99, 80–89, 70–79. In all the patients, the brain atrophy...

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Autores principales: Chrzan, Robert, Gleń, Agnieszka, Bryll, Amira, Urbanik, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801833/
https://www.ncbi.nlm.nih.gov/pubmed/31569457
http://dx.doi.org/10.3390/ijerph16193659
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author Chrzan, Robert
Gleń, Agnieszka
Bryll, Amira
Urbanik, Andrzej
author_facet Chrzan, Robert
Gleń, Agnieszka
Bryll, Amira
Urbanik, Andrzej
author_sort Chrzan, Robert
collection PubMed
description The aim of our study was to compare the degree of brain atrophy in centenarians and in seniors 70–99 years old. The study group consisted of 23 patients aged 100–106 years. The control group consisted of 90 patients, 30 in each age subgroup 90–99, 80–89, 70–79. In all the patients, the brain atrophy linear parameters were measured on computed tomography scans, in relation to both “subcortical atrophy”, evaluated as progressive widening of the ventricular system, and “cortical atrophy”, defined as widening of subarachnoid space. Secondary indices based on the parameters were calculated. Correlations between the above parameters/indices and age were tested. Significantly different values between the centenarians and the control group were found in the brain atrophy parameters: A, B, C, E, FI, ICR, ICL, SW, CFW, F/A ‘frontal horn index’, A/G ‘Evans index’, D/A ‘ventricular index’, H/E ‘cella media Schiersmann index’, A+B ‘Huckman number’. Correlations between parameter/index and age were found for: A, B, C, FI, ICR, ICL, SW, F/A ‘frontal horn index’, A/G ‘Evans index’, D/A ‘ventricular index’, H/E ‘cella media Schiersmann index’, A+B ‘Huckman number’. Brain atrophy associated with aging is a continuously advancing process, affecting centenarians even more than people before the “magic” threshold of 100 years.
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spelling pubmed-68018332019-10-31 Computed Tomography Assessment of Brain Atrophy in Centenarians Chrzan, Robert Gleń, Agnieszka Bryll, Amira Urbanik, Andrzej Int J Environ Res Public Health Article The aim of our study was to compare the degree of brain atrophy in centenarians and in seniors 70–99 years old. The study group consisted of 23 patients aged 100–106 years. The control group consisted of 90 patients, 30 in each age subgroup 90–99, 80–89, 70–79. In all the patients, the brain atrophy linear parameters were measured on computed tomography scans, in relation to both “subcortical atrophy”, evaluated as progressive widening of the ventricular system, and “cortical atrophy”, defined as widening of subarachnoid space. Secondary indices based on the parameters were calculated. Correlations between the above parameters/indices and age were tested. Significantly different values between the centenarians and the control group were found in the brain atrophy parameters: A, B, C, E, FI, ICR, ICL, SW, CFW, F/A ‘frontal horn index’, A/G ‘Evans index’, D/A ‘ventricular index’, H/E ‘cella media Schiersmann index’, A+B ‘Huckman number’. Correlations between parameter/index and age were found for: A, B, C, FI, ICR, ICL, SW, F/A ‘frontal horn index’, A/G ‘Evans index’, D/A ‘ventricular index’, H/E ‘cella media Schiersmann index’, A+B ‘Huckman number’. Brain atrophy associated with aging is a continuously advancing process, affecting centenarians even more than people before the “magic” threshold of 100 years. MDPI 2019-09-29 2019-10 /pmc/articles/PMC6801833/ /pubmed/31569457 http://dx.doi.org/10.3390/ijerph16193659 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chrzan, Robert
Gleń, Agnieszka
Bryll, Amira
Urbanik, Andrzej
Computed Tomography Assessment of Brain Atrophy in Centenarians
title Computed Tomography Assessment of Brain Atrophy in Centenarians
title_full Computed Tomography Assessment of Brain Atrophy in Centenarians
title_fullStr Computed Tomography Assessment of Brain Atrophy in Centenarians
title_full_unstemmed Computed Tomography Assessment of Brain Atrophy in Centenarians
title_short Computed Tomography Assessment of Brain Atrophy in Centenarians
title_sort computed tomography assessment of brain atrophy in centenarians
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801833/
https://www.ncbi.nlm.nih.gov/pubmed/31569457
http://dx.doi.org/10.3390/ijerph16193659
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