Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation

Sulfur metabolism is essential for all living organisms. Recently, unique features of the Entamoeba metabolic pathway for sulfated biomolecules have been described. Entamoeba is a genus in the phylum Amoebozoa and includes the causative agent for amoebiasis, a global public health problem. This revi...

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Detalles Bibliográficos
Autores principales: Mi-ichi, Fumika, Yoshida, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801973/
https://www.ncbi.nlm.nih.gov/pubmed/31546588
http://dx.doi.org/10.3390/ijms20194679
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author Mi-ichi, Fumika
Yoshida, Hiroki
author_facet Mi-ichi, Fumika
Yoshida, Hiroki
author_sort Mi-ichi, Fumika
collection PubMed
description Sulfur metabolism is essential for all living organisms. Recently, unique features of the Entamoeba metabolic pathway for sulfated biomolecules have been described. Entamoeba is a genus in the phylum Amoebozoa and includes the causative agent for amoebiasis, a global public health problem. This review gives an overview of the general features of the synthesis and degradation of sulfated biomolecules, and then highlights the characteristics that are unique to Entamoeba. Future biological and pharmaceutical perspectives are also discussed.
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spelling pubmed-68019732019-10-31 Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation Mi-ichi, Fumika Yoshida, Hiroki Int J Mol Sci Review Sulfur metabolism is essential for all living organisms. Recently, unique features of the Entamoeba metabolic pathway for sulfated biomolecules have been described. Entamoeba is a genus in the phylum Amoebozoa and includes the causative agent for amoebiasis, a global public health problem. This review gives an overview of the general features of the synthesis and degradation of sulfated biomolecules, and then highlights the characteristics that are unique to Entamoeba. Future biological and pharmaceutical perspectives are also discussed. MDPI 2019-09-21 /pmc/articles/PMC6801973/ /pubmed/31546588 http://dx.doi.org/10.3390/ijms20194679 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mi-ichi, Fumika
Yoshida, Hiroki
Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation
title Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation
title_full Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation
title_fullStr Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation
title_full_unstemmed Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation
title_short Unique Features of Entamoeba Sulfur Metabolism; Compartmentalization, Physiological Roles of Terminal Products, Evolution and Pharmaceutical Exploitation
title_sort unique features of entamoeba sulfur metabolism; compartmentalization, physiological roles of terminal products, evolution and pharmaceutical exploitation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801973/
https://www.ncbi.nlm.nih.gov/pubmed/31546588
http://dx.doi.org/10.3390/ijms20194679
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AT yoshidahiroki uniquefeaturesofentamoebasulfurmetabolismcompartmentalizationphysiologicalrolesofterminalproductsevolutionandpharmaceuticalexploitation

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