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Structure-Based Design and in Silico Screening of Virtual Combinatorial Library of Benzamides Inhibiting 2-trans Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Predicted Pharmacokinetic Profiles

Background: During the previous decade a new class of benzamide-based inhibitors of 2-trans enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (Mt) with unusual binding mode have emerged. Here we report in silico design and evaluation of novel benzamide InhA-Mt inhibitors with...

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Detalles Bibliográficos
Autores principales:	Kouman, Koffi Charles, Keita, Melalie, Kre N’Guessan, Raymond, Owono Owono, Luc Calvin, Megnassan, Eugene, Frecer, Vladimir, Miertus, Stanislav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802012/ https://www.ncbi.nlm.nih.gov/pubmed/31554227 http://dx.doi.org/10.3390/ijms20194730

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