Evaluation of Small Molecule Drug Uptake in Patient-Derived Prostate Cancer Explants by Mass Spectrometry

Patient-derived explant (PDE) culture of solid tumors is increasingly being applied to preclinical evaluation of novel therapeutics and for biomarker discovery. In this technique, treatments are added to culture medium and penetrate the tissue via a gelatin sponge scaffold. However, the penetration...

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Detalles Bibliográficos
Autores principales: Mutuku, Shadrack M., Trim, Paul J., Prabhala, Bala K., Irani, Swati, Bremert, Kayla L., Logan, Jessica M., Brooks, Douglas A., Stahl, Jürgen, Centenera, Margaret M., Snel, Marten F., Butler, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802206/
https://www.ncbi.nlm.nih.gov/pubmed/31628408
http://dx.doi.org/10.1038/s41598-019-51549-3

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