Cargando…
Identification of atrial fibrillation associated genes and functional non-coding variants
Disease-associated genetic variants that lie in non-coding regions found by genome-wide association studies are thought to alter the functionality of transcription regulatory elements and target gene expression. To uncover causal genetic variants, variant regulatory elements and their target genes,...
Autores principales: | van Ouwerkerk, Antoinette F., Bosada, Fernanda M., van Duijvenboden, Karel, Hill, Matthew C., Montefiori, Lindsey E., Scholman, Koen T., Liu, Jia, de Vries, Antoine A. F., Boukens, Bastiaan J., Ellinor, Patrick T., Goumans, Marie José T. H., Efimov, Igor R., Nobrega, Marcelo A., Barnett, Phil, Martin, James F., Christoffels, Vincent M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802215/ https://www.ncbi.nlm.nih.gov/pubmed/31628324 http://dx.doi.org/10.1038/s41467-019-12721-5 |
Ejemplares similares
-
Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction
por: van Ouwerkerk, Antoinette F., et al.
Publicado: (2022) -
An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility
por: Bosada, Fernanda M, et al.
Publicado: (2023) -
Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction
por: van Weerd, Jan Hendrik, et al.
Publicado: (2020) -
GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development
por: Stefanovic, Sonia, et al.
Publicado: (2014) -
From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity
por: Scholman, Koen T., et al.
Publicado: (2020)