Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy

We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 da...

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Autores principales: Hyun, Hoon, Yoo, Young Bum, Kim, So Yeon, Ko, Hyun Sun, Chun, Heung Jae, Yang, Dae Hyeok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802362/
https://www.ncbi.nlm.nih.gov/pubmed/31547111
http://dx.doi.org/10.3390/ijms20194671
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author Hyun, Hoon
Yoo, Young Bum
Kim, So Yeon
Ko, Hyun Sun
Chun, Heung Jae
Yang, Dae Hyeok
author_facet Hyun, Hoon
Yoo, Young Bum
Kim, So Yeon
Ko, Hyun Sun
Chun, Heung Jae
Yang, Dae Hyeok
author_sort Hyun, Hoon
collection PubMed
description We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 days and remained so thereafter. After an initial burst period of 7 hours, the two drugs were released in a sustained manner for 7 days. The in vitro cell viability test showed that GDCP had a better anticancer effect than well plate and DOX⋅HCl/PTX (DP). In addition, the in vivo tests, which evaluated the anticancer effect, systemic toxicity, and histology, proved the feasibility of GDCP as a clinical therapy for breast cancer.
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spelling pubmed-68023622019-11-18 Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy Hyun, Hoon Yoo, Young Bum Kim, So Yeon Ko, Hyun Sun Chun, Heung Jae Yang, Dae Hyeok Int J Mol Sci Article We used a hydrogel-mediated dual drug delivery approach, based on an injectable glycol chitosan (GC) hydrogel, doxorubicin hydrochloride (DOX⋅HCl), and a complex of beta-cyclodextrin (β-CD) and paclitaxel (PTX) (GDCP) for breast cancer therapy in vitro and in vivo. The hydrogel was swollen over 3 days and remained so thereafter. After an initial burst period of 7 hours, the two drugs were released in a sustained manner for 7 days. The in vitro cell viability test showed that GDCP had a better anticancer effect than well plate and DOX⋅HCl/PTX (DP). In addition, the in vivo tests, which evaluated the anticancer effect, systemic toxicity, and histology, proved the feasibility of GDCP as a clinical therapy for breast cancer. MDPI 2019-09-20 /pmc/articles/PMC6802362/ /pubmed/31547111 http://dx.doi.org/10.3390/ijms20194671 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hyun, Hoon
Yoo, Young Bum
Kim, So Yeon
Ko, Hyun Sun
Chun, Heung Jae
Yang, Dae Hyeok
Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy
title Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy
title_full Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy
title_fullStr Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy
title_full_unstemmed Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy
title_short Hydrogel-Mediated DOX⋅HCl/PTX Delivery System for Breast Cancer Therapy
title_sort hydrogel-mediated dox⋅hcl/ptx delivery system for breast cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802362/
https://www.ncbi.nlm.nih.gov/pubmed/31547111
http://dx.doi.org/10.3390/ijms20194671
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