SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis

During ligand-mediated receptor endocytosis, the small GTPase Rab5 functions in vesicle fusion and trafficking. Rab5 activation is known to require interactions with its guanine nucleotide-exchange factors (GEFs); however, the mechanism regulating Rab5 interactions with GEFs remains unclear. Here, w...

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Detalles Bibliográficos
Autores principales: Kim, Hwan, Oh, Hyejin, Oh, Young Soo, Bae, Jeomil, Hong, Nan Hyung, Park, Su Jung, Ahn, Suyeon, Lee, Miriam, Rhee, Sangmyung, Lee, Sung Haeng, Jun, Youngsoo, Kim, Sung Hyun, Huh, Yun Hyun, Song, Woo Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802610/
https://www.ncbi.nlm.nih.gov/pubmed/31358736
http://dx.doi.org/10.1038/s12276-019-0284-5

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