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Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation

Dyslipidemia-induced atherosclerosis, which has a risk of high morbidity and mortality, can be alleviated by metabolic activation associated with mitochondrial function. The effect of dichloroacetate (DCA), a general pyruvate dehydrogenase kinase (PDK) inhibitor, on in vivo energy expenditure in Apo...

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Detalles Bibliográficos
Autores principales:	Min, Byong-Keol, Oh, Chang Joo, Park, Sungmi, Lee, Ji-Min, Go, Younghoon, Park, Bo-Yoon, Kang, Hyeon-Ji, Kim, Dong Wook, Kim, Jeong-Eun, Yoo, Eun Kyung, Kim, Hui Eon, Kim, Mi-Jin, Jeon, Yong Hyun, Kim, Yong-Hoon, Lee, Chul-Ho, Jeon, Jae-Han, Lee, In-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802614/ https://www.ncbi.nlm.nih.gov/pubmed/31570705 http://dx.doi.org/10.1038/s12276-019-0315-2

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