Cargando…
Deacetylation of XBP1s by sirtuin 6 confers resistance to ER stress-induced hepatic steatosis
The active spliced form of X-box-binding protein 1 (XBP1s) is a key modulator of ER stress, but the functional role of its post-translational modification remains unclear. Here, we demonstrate that XBP1s is a deacetylation target of Sirt6 and that its deacetylation protects against ER stress-induced...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802632/ https://www.ncbi.nlm.nih.gov/pubmed/31541078 http://dx.doi.org/10.1038/s12276-019-0309-0 |