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Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles

[Image: see text] N3-Methyl-2′-deoxyadenosine (MdA) is the major dA methylation product in duplex DNA. MdA blocks DNA replication and undergoes depurination at significantly higher rates than the native nucleotide from which it is derived. Recent reports on the effects of the nucleosome core particl...

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Detalles Bibliográficos
Autores principales:	Yang, Kun, Sun, Huabing, Lowder, Leah, Varadarajan, Sridhar, Greenberg, Marc M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2019
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803048/ https://www.ncbi.nlm.nih.gov/pubmed/31565933 http://dx.doi.org/10.1021/acs.chemrestox.9b00299

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