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Recent advances in traumatic brain injury
Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge. There has been a secular trend towards reduced inciden...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803592/ https://www.ncbi.nlm.nih.gov/pubmed/31563989 http://dx.doi.org/10.1007/s00415-019-09541-4 |
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author | Khellaf, Abdelhakim Khan, Danyal Zaman Helmy, Adel |
author_facet | Khellaf, Abdelhakim Khan, Danyal Zaman Helmy, Adel |
author_sort | Khellaf, Abdelhakim |
collection | PubMed |
description | Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge. There has been a secular trend towards reduced incidence of severe TBI in the first world, driven by public health interventions such as seatbelt legislation, helmet use, and workplace health and safety regulations. This has paralleled improved outcomes following TBI delivered in a large part by the widespread establishment of specialised neurointensive care. This update will focus on three key areas of advances in TBI management and research in moderate and severe TBI: refining neurointensive care protocolized therapies, the recent evidence base for decompressive craniectomy and novel pharmacological therapies. In each section, we review the developing evidence base as well as exploring future trajectories of TBI research. |
format | Online Article Text |
id | pubmed-6803592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-68035922019-11-05 Recent advances in traumatic brain injury Khellaf, Abdelhakim Khan, Danyal Zaman Helmy, Adel J Neurol Neurological Update Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge. There has been a secular trend towards reduced incidence of severe TBI in the first world, driven by public health interventions such as seatbelt legislation, helmet use, and workplace health and safety regulations. This has paralleled improved outcomes following TBI delivered in a large part by the widespread establishment of specialised neurointensive care. This update will focus on three key areas of advances in TBI management and research in moderate and severe TBI: refining neurointensive care protocolized therapies, the recent evidence base for decompressive craniectomy and novel pharmacological therapies. In each section, we review the developing evidence base as well as exploring future trajectories of TBI research. Springer Berlin Heidelberg 2019-09-28 2019 /pmc/articles/PMC6803592/ /pubmed/31563989 http://dx.doi.org/10.1007/s00415-019-09541-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Neurological Update Khellaf, Abdelhakim Khan, Danyal Zaman Helmy, Adel Recent advances in traumatic brain injury |
title | Recent advances in traumatic brain injury |
title_full | Recent advances in traumatic brain injury |
title_fullStr | Recent advances in traumatic brain injury |
title_full_unstemmed | Recent advances in traumatic brain injury |
title_short | Recent advances in traumatic brain injury |
title_sort | recent advances in traumatic brain injury |
topic | Neurological Update |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803592/ https://www.ncbi.nlm.nih.gov/pubmed/31563989 http://dx.doi.org/10.1007/s00415-019-09541-4 |
work_keys_str_mv | AT khellafabdelhakim recentadvancesintraumaticbraininjury AT khandanyalzaman recentadvancesintraumaticbraininjury AT helmyadel recentadvancesintraumaticbraininjury |