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Recent advances in traumatic brain injury

Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge. There has been a secular trend towards reduced inciden...

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Autores principales: Khellaf, Abdelhakim, Khan, Danyal Zaman, Helmy, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803592/
https://www.ncbi.nlm.nih.gov/pubmed/31563989
http://dx.doi.org/10.1007/s00415-019-09541-4
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author Khellaf, Abdelhakim
Khan, Danyal Zaman
Helmy, Adel
author_facet Khellaf, Abdelhakim
Khan, Danyal Zaman
Helmy, Adel
author_sort Khellaf, Abdelhakim
collection PubMed
description Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge. There has been a secular trend towards reduced incidence of severe TBI in the first world, driven by public health interventions such as seatbelt legislation, helmet use, and workplace health and safety regulations. This has paralleled improved outcomes following TBI delivered in a large part by the widespread establishment of specialised neurointensive care. This update will focus on three key areas of advances in TBI management and research in moderate and severe TBI: refining neurointensive care protocolized therapies, the recent evidence base for decompressive craniectomy and novel pharmacological therapies. In each section, we review the developing evidence base as well as exploring future trajectories of TBI research.
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spelling pubmed-68035922019-11-05 Recent advances in traumatic brain injury Khellaf, Abdelhakim Khan, Danyal Zaman Helmy, Adel J Neurol Neurological Update Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge. There has been a secular trend towards reduced incidence of severe TBI in the first world, driven by public health interventions such as seatbelt legislation, helmet use, and workplace health and safety regulations. This has paralleled improved outcomes following TBI delivered in a large part by the widespread establishment of specialised neurointensive care. This update will focus on three key areas of advances in TBI management and research in moderate and severe TBI: refining neurointensive care protocolized therapies, the recent evidence base for decompressive craniectomy and novel pharmacological therapies. In each section, we review the developing evidence base as well as exploring future trajectories of TBI research. Springer Berlin Heidelberg 2019-09-28 2019 /pmc/articles/PMC6803592/ /pubmed/31563989 http://dx.doi.org/10.1007/s00415-019-09541-4 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Neurological Update
Khellaf, Abdelhakim
Khan, Danyal Zaman
Helmy, Adel
Recent advances in traumatic brain injury
title Recent advances in traumatic brain injury
title_full Recent advances in traumatic brain injury
title_fullStr Recent advances in traumatic brain injury
title_full_unstemmed Recent advances in traumatic brain injury
title_short Recent advances in traumatic brain injury
title_sort recent advances in traumatic brain injury
topic Neurological Update
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803592/
https://www.ncbi.nlm.nih.gov/pubmed/31563989
http://dx.doi.org/10.1007/s00415-019-09541-4
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