Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series

Idiopathic nephrotic syndrome (INS) represents 15%–30% of adulthood glomerulopathies. Corticosteroids have been the main treatment for decades and are effective in 70% of minimal-change disease patients and ~30% of focal segmental glomerulosclerosis patients. Multidrug-resistant (steroids, calcineur...

Descripción completa

Detalles Bibliográficos
Autores principales: Naciri Bennani, Hamza, Jouve, Thomas, Noble, Johan, Rostaing, Lionel, Malvezzi, Paolo, Tetaz, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803719/
https://www.ncbi.nlm.nih.gov/pubmed/31687235
http://dx.doi.org/10.1155/2019/7304786
_version_ 1783461006075232256
author Naciri Bennani, Hamza
Jouve, Thomas
Noble, Johan
Rostaing, Lionel
Malvezzi, Paolo
Tetaz, Rachel
author_facet Naciri Bennani, Hamza
Jouve, Thomas
Noble, Johan
Rostaing, Lionel
Malvezzi, Paolo
Tetaz, Rachel
author_sort Naciri Bennani, Hamza
collection PubMed
description Idiopathic nephrotic syndrome (INS) represents 15%–30% of adulthood glomerulopathies. Corticosteroids have been the main treatment for decades and are effective in 70% of minimal-change disease patients and ~30% of focal segmental glomerulosclerosis patients. Multidrug-resistant (steroids, calcineurin-inhibitors, cyclophosphamide, mycophenolate-mofetil, rituximab) idiopathic nephrotic syndrome is a major therapeutic challenge in nephrology. Apheresis (double-filtration plasmapheresis or semi specific immunoadsorption) could act by eliminating the circulating factor (apolipoproteinA1b, solubleCD40L, suPAR) increasing glomerular permeability seen in INS. The aim of the study was to report the outcome of three patients with multidrug-resistant INS treated successfully with apheresis.
format Online
Article
Text
id pubmed-6803719
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-68037192019-11-04 Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series Naciri Bennani, Hamza Jouve, Thomas Noble, Johan Rostaing, Lionel Malvezzi, Paolo Tetaz, Rachel Case Rep Nephrol Case Report Idiopathic nephrotic syndrome (INS) represents 15%–30% of adulthood glomerulopathies. Corticosteroids have been the main treatment for decades and are effective in 70% of minimal-change disease patients and ~30% of focal segmental glomerulosclerosis patients. Multidrug-resistant (steroids, calcineurin-inhibitors, cyclophosphamide, mycophenolate-mofetil, rituximab) idiopathic nephrotic syndrome is a major therapeutic challenge in nephrology. Apheresis (double-filtration plasmapheresis or semi specific immunoadsorption) could act by eliminating the circulating factor (apolipoproteinA1b, solubleCD40L, suPAR) increasing glomerular permeability seen in INS. The aim of the study was to report the outcome of three patients with multidrug-resistant INS treated successfully with apheresis. Hindawi 2019-10-09 /pmc/articles/PMC6803719/ /pubmed/31687235 http://dx.doi.org/10.1155/2019/7304786 Text en Copyright © 2019 Hamza Naciri Bennani et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Naciri Bennani, Hamza
Jouve, Thomas
Noble, Johan
Rostaing, Lionel
Malvezzi, Paolo
Tetaz, Rachel
Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series
title Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series
title_full Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series
title_fullStr Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series
title_full_unstemmed Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series
title_short Apheresis Therapy for Steroid-Resistant Idiopathic Nephrotic Syndrome: Report on a Case Series
title_sort apheresis therapy for steroid-resistant idiopathic nephrotic syndrome: report on a case series
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803719/
https://www.ncbi.nlm.nih.gov/pubmed/31687235
http://dx.doi.org/10.1155/2019/7304786
work_keys_str_mv AT naciribennanihamza apheresistherapyforsteroidresistantidiopathicnephroticsyndromereportonacaseseries
AT jouvethomas apheresistherapyforsteroidresistantidiopathicnephroticsyndromereportonacaseseries
AT noblejohan apheresistherapyforsteroidresistantidiopathicnephroticsyndromereportonacaseseries
AT rostainglionel apheresistherapyforsteroidresistantidiopathicnephroticsyndromereportonacaseseries
AT malvezzipaolo apheresistherapyforsteroidresistantidiopathicnephroticsyndromereportonacaseseries
AT tetazrachel apheresistherapyforsteroidresistantidiopathicnephroticsyndromereportonacaseseries

Ejemplares similares