Cargando…
Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study
BACKGROUND: Determining liver biomarkers can help to screen and facilitate early management of potential liver diseases. However, such studies are scarce in the present study area. Therefore, our study planned to assess the prevalence of liver function test abnormality and associated factors among T...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Communications and Publications Division (CPD) of the IFCC
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803769/ https://www.ncbi.nlm.nih.gov/pubmed/31695587 |
_version_ | 1783461018788167680 |
---|---|
author | Teshome, Getnet Ambachew, Sintayehu Fasil, Alebachew Abebe, Molla |
author_facet | Teshome, Getnet Ambachew, Sintayehu Fasil, Alebachew Abebe, Molla |
author_sort | Teshome, Getnet |
collection | PubMed |
description | BACKGROUND: Determining liver biomarkers can help to screen and facilitate early management of potential liver diseases. However, such studies are scarce in the present study area. Therefore, our study planned to assess the prevalence of liver function test abnormality and associated factors among Type 2 Diabetes Mellitus (T2DM) patients. METHODS: A comparative cross-sectional study was conducted at the University of Gondar Comprehensive Specialized Hospital from January 1, 2018 to May 20, 2018 among 159 T2DM patients and 159 nondiabetic controls. Clinical, lifestyle, anthropometric data and 5 ml of blood were collected from all study subjects. Liver function tests (LFTs), lipid profiles and fasting blood sugar were determined. Systematic random sampling technique was used to select the study subjects. Binary logistic regression and bivariate correlation was used to assess association of factors with outcomes and p value of ≤0.05 was considered as significant. RESULTS: Overall, 53 (33.3%) of T2DM had one or more liver test abnormality above the upper limit of the normal (ULN) reference range. Alanine aminotransferase was the most frequently raised liver enzyme in T2DM (n=37, 23.3%). The mean value of LFTs was significantly different between T2DM and the control group. Alcohol drink, sex and age were found to be a significant factor for impairment of LFTs. CONCLUSION: The prevalence of abnormal LFTs was higher in T2DM patients than nondiabetic control group. Hence, we recommended the utilization of LFTs to monitor liver conditions in T2DM patients. |
format | Online Article Text |
id | pubmed-6803769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Communications and Publications Division (CPD) of the IFCC |
record_format | MEDLINE/PubMed |
spelling | pubmed-68037692019-11-06 Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study Teshome, Getnet Ambachew, Sintayehu Fasil, Alebachew Abebe, Molla EJIFCC Research Article BACKGROUND: Determining liver biomarkers can help to screen and facilitate early management of potential liver diseases. However, such studies are scarce in the present study area. Therefore, our study planned to assess the prevalence of liver function test abnormality and associated factors among Type 2 Diabetes Mellitus (T2DM) patients. METHODS: A comparative cross-sectional study was conducted at the University of Gondar Comprehensive Specialized Hospital from January 1, 2018 to May 20, 2018 among 159 T2DM patients and 159 nondiabetic controls. Clinical, lifestyle, anthropometric data and 5 ml of blood were collected from all study subjects. Liver function tests (LFTs), lipid profiles and fasting blood sugar were determined. Systematic random sampling technique was used to select the study subjects. Binary logistic regression and bivariate correlation was used to assess association of factors with outcomes and p value of ≤0.05 was considered as significant. RESULTS: Overall, 53 (33.3%) of T2DM had one or more liver test abnormality above the upper limit of the normal (ULN) reference range. Alanine aminotransferase was the most frequently raised liver enzyme in T2DM (n=37, 23.3%). The mean value of LFTs was significantly different between T2DM and the control group. Alcohol drink, sex and age were found to be a significant factor for impairment of LFTs. CONCLUSION: The prevalence of abnormal LFTs was higher in T2DM patients than nondiabetic control group. Hence, we recommended the utilization of LFTs to monitor liver conditions in T2DM patients. The Communications and Publications Division (CPD) of the IFCC 2019-10-11 /pmc/articles/PMC6803769/ /pubmed/31695587 Text en Copyright © 2019 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Teshome, Getnet Ambachew, Sintayehu Fasil, Alebachew Abebe, Molla Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study |
title | Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study |
title_full | Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study |
title_fullStr | Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study |
title_full_unstemmed | Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study |
title_short | Prevalence of Liver Function Test Abnormality and Associated Factors in Type 2 Diabetes Mellitus: A Comparative Cross-Sectional Study |
title_sort | prevalence of liver function test abnormality and associated factors in type 2 diabetes mellitus: a comparative cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803769/ https://www.ncbi.nlm.nih.gov/pubmed/31695587 |
work_keys_str_mv | AT teshomegetnet prevalenceofliverfunctiontestabnormalityandassociatedfactorsintype2diabetesmellitusacomparativecrosssectionalstudy AT ambachewsintayehu prevalenceofliverfunctiontestabnormalityandassociatedfactorsintype2diabetesmellitusacomparativecrosssectionalstudy AT fasilalebachew prevalenceofliverfunctiontestabnormalityandassociatedfactorsintype2diabetesmellitusacomparativecrosssectionalstudy AT abebemolla prevalenceofliverfunctiontestabnormalityandassociatedfactorsintype2diabetesmellitusacomparativecrosssectionalstudy |