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The exercise pressor reflex and active O(2) transport in peripheral arterial disease
It is unclear if the exaggerated exercise pressor reflex observed in peripheral arterial disease (PAD) patients facilitates Oxygen (O(2)) transport during presymptomatic exercise. Accordingly, this study compared O(2) transport between PAD patients and healthy controls during graded presymptomatic w...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803779/ https://www.ncbi.nlm.nih.gov/pubmed/31637857 http://dx.doi.org/10.14814/phy2.14243 |
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author | Stavres, Jon Sica, Christopher T. Blaha, Cheryl Herr, Michael Wang, Jianli Pai, Samuel Cauffman, Aimee Vesek, Jeffrey Yang, Qing X. Sinoway, Lawrence I. |
author_facet | Stavres, Jon Sica, Christopher T. Blaha, Cheryl Herr, Michael Wang, Jianli Pai, Samuel Cauffman, Aimee Vesek, Jeffrey Yang, Qing X. Sinoway, Lawrence I. |
author_sort | Stavres, Jon |
collection | PubMed |
description | It is unclear if the exaggerated exercise pressor reflex observed in peripheral arterial disease (PAD) patients facilitates Oxygen (O(2)) transport during presymptomatic exercise. Accordingly, this study compared O(2) transport between PAD patients and healthy controls during graded presymptomatic work. Seven PAD patients and seven healthy controls performed dynamic plantar flexion in the bore of a 3T MRI scanner. Perfusion, T(2)* (an index of relative tissue oxygenation), and SvO(2) (a measure of venous oxygen saturation) were collected from the medial gastrocnemius (MG) during the final 10 seconds of each stage. Blood pressure was also collected during the final minute of each stage. As expected, the pressor response to presymptomatic work (4 kg) was exaggerated in PAD patients compared to controls (+14 mmHg ± 4 and +7 mmHg ± 2, P ≤ 0.034). When normalized to changes in free water content (S(0)), T(2)* was lower at 2 kg in PAD patients compared to controls (−0.91 Δms/ΔAU ± 0.3 and 0.57 Δms/ΔAU ± 0.3, P ≤ 0.008); followed by a greater increase in perfusion at 4 kg in the PAD group (+18.8 mL/min/100g ± 6.2 vs. −0.21 mL/min/100g ± 3.2 in PAD and controls, P ≤ 0.026). Lastly, SvO(2) decreased at 4 kg in both groups (−13% ± 4 and −2% ± 4 in PAD and controls, P ≤ 0.049), suggesting an increase in O(2) extraction in the PAD group. Based on these findings, O(2) transport appears to be augmented during graded presymptomatic work in PAD patients, and this may be partially mediated by an exaggerated pressor response. |
format | Online Article Text |
id | pubmed-6803779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-68037792019-10-24 The exercise pressor reflex and active O(2) transport in peripheral arterial disease Stavres, Jon Sica, Christopher T. Blaha, Cheryl Herr, Michael Wang, Jianli Pai, Samuel Cauffman, Aimee Vesek, Jeffrey Yang, Qing X. Sinoway, Lawrence I. Physiol Rep Original Research It is unclear if the exaggerated exercise pressor reflex observed in peripheral arterial disease (PAD) patients facilitates Oxygen (O(2)) transport during presymptomatic exercise. Accordingly, this study compared O(2) transport between PAD patients and healthy controls during graded presymptomatic work. Seven PAD patients and seven healthy controls performed dynamic plantar flexion in the bore of a 3T MRI scanner. Perfusion, T(2)* (an index of relative tissue oxygenation), and SvO(2) (a measure of venous oxygen saturation) were collected from the medial gastrocnemius (MG) during the final 10 seconds of each stage. Blood pressure was also collected during the final minute of each stage. As expected, the pressor response to presymptomatic work (4 kg) was exaggerated in PAD patients compared to controls (+14 mmHg ± 4 and +7 mmHg ± 2, P ≤ 0.034). When normalized to changes in free water content (S(0)), T(2)* was lower at 2 kg in PAD patients compared to controls (−0.91 Δms/ΔAU ± 0.3 and 0.57 Δms/ΔAU ± 0.3, P ≤ 0.008); followed by a greater increase in perfusion at 4 kg in the PAD group (+18.8 mL/min/100g ± 6.2 vs. −0.21 mL/min/100g ± 3.2 in PAD and controls, P ≤ 0.026). Lastly, SvO(2) decreased at 4 kg in both groups (−13% ± 4 and −2% ± 4 in PAD and controls, P ≤ 0.049), suggesting an increase in O(2) extraction in the PAD group. Based on these findings, O(2) transport appears to be augmented during graded presymptomatic work in PAD patients, and this may be partially mediated by an exaggerated pressor response. John Wiley and Sons Inc. 2019-10-22 /pmc/articles/PMC6803779/ /pubmed/31637857 http://dx.doi.org/10.14814/phy2.14243 Text en © 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Stavres, Jon Sica, Christopher T. Blaha, Cheryl Herr, Michael Wang, Jianli Pai, Samuel Cauffman, Aimee Vesek, Jeffrey Yang, Qing X. Sinoway, Lawrence I. The exercise pressor reflex and active O(2) transport in peripheral arterial disease |
title | The exercise pressor reflex and active O(2) transport in peripheral arterial disease |
title_full | The exercise pressor reflex and active O(2) transport in peripheral arterial disease |
title_fullStr | The exercise pressor reflex and active O(2) transport in peripheral arterial disease |
title_full_unstemmed | The exercise pressor reflex and active O(2) transport in peripheral arterial disease |
title_short | The exercise pressor reflex and active O(2) transport in peripheral arterial disease |
title_sort | exercise pressor reflex and active o(2) transport in peripheral arterial disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803779/ https://www.ncbi.nlm.nih.gov/pubmed/31637857 http://dx.doi.org/10.14814/phy2.14243 |
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